妊娠期糖尿病并发子痫前期影响因素的Meta分析  

Meta-analysis of influencing factors of gestational diabetes mellitus complicated with preeclampsia

作　　者：邓斯琪 何伶俐[1] 贾晓宙 DENG Siqi;HE Lingli;JIA Xiaozhou(The Second Department of Obstetrics,Hunan Provincial Maternal and Child Health Care Hospital,Changsha 410008,China)

机构地区：[1]湖南省妇幼保健院产二科,长沙410008

出　　处：《中国临床新医学》2025年第3期335-342,共8页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：湖南创新型省份建设专项(编号:2020SK4011);长沙市自然科学基金项目(编号:kq2202471)。

摘　　要：目的通过Meta分析评价妊娠期糖尿病(GDM)并发子痫前期的影响因素。方法使用计算机检索中国知网、维普网、中国生物医学数据库、万方数据知识服务平台、PubMed、Embase、EBSCO、Web of Science、the Cochrane Library、CINAHL、JBI中关于GDM并发子痫前期的文献,检索时限为建库至2024年10月11日。应用RevMan 5.3和STATA 16.0软件进行数据分析。结果共纳入13篇文献,合计样本量为4999例。Meta分析结果显示,高血压家族史[OR(95%CI)=2.23(1.20~4.15)]、体质量指数(BMI)[OR(95%CI)=2.60(1.72~3.93)]、总胆固醇(TC)[OR(95%CI)=1.32(1.11~1.57)]、合并妊娠期高血压[OR(95%CI)=7.74(2.70~22.20)]、血糖控制情况[OR(95%CI)=5.83(2.29~14.84)]是GDM并发子痫前期的影响因素,差异有统计学意义(P<0.05)。空腹血糖(FPG)、同型半胱氨酸(Hcy)、产次、孕期增加体质量、血糖水平、年龄、1型糖尿病、收缩压>120 mmHg对GDM并发子痫前期的影响未显示出统计学意义(P>0.05)。结论高血压家族史、BMI、TC、合并妊娠期高血压、血糖控制情况是GDM并发子痫前期的影响因素。Objective To evaluate the influencing factors of gestational diabetes mellitus(GDM)complicated with preeclampsia by using Meta-analysis.Methods The literature on GDM complicated with preeclampsia in China National Knowledge Infrastructure(CNKI),VIP,China Biology Medicine disc(CBMdisc),Wanfang Data Knowledge Service Platform,PubMed,Embase,EBSCO,Web of Science,the Cochrane Library,Cumulative Index to Nursing and Allied Health Literature(CINAHL)and Joanna Briggs Institute(JBI)were searched by using computer.The publication time of the searched papers ranged from the establishment of each database to October 11,2024.RevMan 5.3 and STATA 16.0 softwares were used for data analysis.Results A total of 13 papers were included in this study,with a total sample size of 4999 cases.The results of Meta-analysis showed that family history of hypertension[OR(95%CI)=2.23(1.20-4.15)],body mass index(BMI)[OR(95%CI)=2.60(1.72-3.93)],total cholesterol(TC)[OR(95%CI)=1.32(1.11-1.57)],complicating gestational hypertension[OR(95%CI)=7.74(2.70-22.20)]and glycemic control status[OR(95%CI)=5.83(2.29-14.84)]were the influencing factors of GDM complicated with preeclampsia,and the differences were statistically significant(P<0.05).The effects of fasting plasma glucose(FPG),homocysteine(Hcy),parity,increased body mass during pregnancy,blood glucose level,age,type 1 diabetes mellitus and systolic blood pressure>120 mmHg on GDM complicated with preeclampsia were not statistically significant(P>0.05).Conclusion Family history of hypertension,BMI,TC,complicating gestational hypertension and glycemic control status are the influencing factors of GDM complicated with preeclampsia.

关 键 词：妊娠期糖尿病 子痫前期 影响因素 META分析 

分 类 号：R714[医药卫生—妇产科学]