奶牛源葡萄球菌对大环内酯类抗生素耐药机制及大环内酯类创新药物的研发进展  

Mechanism of Resistance of Milk-derived Staphylococcus to Macrolides and Progress of Research and Development of Innovative Macrolide Drugs

作　　者：朱石荻 邵丽莹 刘义明[1] 冯善麟 徐飞[1] 李秀波[1] 陈孝杰 ZHU Shi-di;SHAO Li-ying;LIU Yi-ming;FENG Shan-lin;XU Fei;LI Xiu-bo;CHEN Xiao-jie(Feed Research Institute/Key Laboratory of Antimicrobial Resistance Surveillance of Animal-Derived Bacteria,Ministry of Agriculture and Rural Affairs/National Benchmark Laboratory for Drugs in Feed,Chinese Academy of Agricultural Sciences,Beijing 100081,China;Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry,College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300392,China.)

机构地区：[1]中国农业科学院饲料研究所,农业农村部动物源细菌耐药性监测重点实验室,国家饲料中药物基准实验室,北京100081 [2]天津农学院动物科学与动物医学学院,天津市农业动物繁育与健康养殖重点实验室,天津300392

出　　处：《中国兽药杂志》2025年第3期52-62,共11页Chinese Journal of Veterinary Drug

基　　金：中国农业科学院创新工程专项所级重点任务:动物养殖绿色投入品创制(CAAS-IFR-ZDRW202302);国家重点研发计划:高效消杀药物新工艺研究与产品创制(2023YFD1800905)。

摘　　要：奶牛乳房炎是奶牛乳腺组织的炎症,葡萄球菌是主要致病菌之一。大环内酯类抗生素常用于治疗革兰氏阳性(G^(+))菌感染引起的炎症,药物滥用导致葡萄球菌对该类药物的耐药性严重。归纳了当前葡萄球菌对大环内酯类抗生素耐药现状,并深入分析其耐药机制,包括靶位突变、基因修饰等;对新型大环内酯类抗生素及抗菌增效剂研发方法、要点及当前进展作了重点综述,以期为相关研究提供参考。Mastitis in dairy cows refers to the inflammation of the mammary gland tissue,with Staphylococcus being one of the major pathogenic bacteria.Macrolide antibiotics are frequently employed in the treatment of inflammations caused by Gram-positive(G^(+))bacterial infections.However,the abuse of drugs has resulted in a severe resistance of Staphylococcus to this class of drugs.The current situation of Staphylococcus'resistance to macrolide antibiotics is summarized herein,and an in-depth analysis of the resistance mechanisms,including target site mutations and gene modifications,is conducted.A key review of the research and development methods,key points,and current progress of novel macrolide antibiotics and antibacterial potentiators is presented,with the expectation of providing references for related studies.

关 键 词：奶牛乳房炎 葡萄球菌 大环内酯类抗生素 耐药机制 新药研发 

分 类 号：S859.796[农业科学—临床兽医学]