小动物体外膜氧合模型的研究进展  

Research Progress on Small Animal Models of Extracorporeal Membrane Oxygenation

作　　者：柳含莹 范春超 郭君妍 陈虹 王淼 LIU Hanying;FAN Chunchao;GUO Junyan;CHEN Hong;WANG Miao(College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua 321000,China;State Key Laboratory of Cardiovascular Diseases,National Center for Cardiovascular Diseases and Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;National Health Commission Cardiovascular Disease Regenerative Medicine Research Key Laboratory,Central China Subcenter of National Center for Cardiovascular Diseases,Henan Cardiovascular Disease Center,Fuwai Central-China Cardiovascular Hospital,Central China Fuwai Hospital of Zhengzhou University,Zhengzhou 450046,China)

机构地区：[1]浙江师范大学生命科学学院,金华321000 [2]中国医学科学院、北京协和医学院、国家心血管病中心、阜外医院心血管疾病国家重点实验室,北京100037 [3]国家卫健委心血管疾病再生医学研究重点实验室、国家心血管病中心华中分中心、河南心血管病中心、阜外华中心血管病医院、郑州大学华中阜外医院,郑州450046

出　　处：《中国循环杂志》2025年第3期302-307,共6页Chinese Circulation Journal

基　　金：国家重点研发计划(2023YFE0118800);国家自然科学基金(82320108002,92149305);中国医学科学院医学与健康科技创新工程目(2021-I2M-1-016);中国医学科学院阜外医院高水平医院临床科研业务费(零余额2022-GSP-GG-8)。

摘　　要：体外膜氧合(ECMO)为重症心肺衰竭患者提供辅助呼吸的血液循环,为危重症的抢救赢得宝贵的时间。然而,ECMO技术往往与严重的并发症有关。小动物具有价格低、来源广、灵活性高、重复性好等优点,是研究ECMO并发症防治和疾病治疗的有效平台。近年来,越来越多的实验研究采用小动物ECMO模型进行。本文就目前国内外小动物ECMO模型的构建和应用现状进行探讨,以期优化小动物ECMO模型构建相关策略,推动小动物ECMO模型的应用发展。Extracorporeal membrane oxygenation(ECMO)provides blood circulation with assisted breathing for patients with severe cardiopulmonary failure,and buys valuable time for the rescue of critical patients.However,extracorporeal membrane oxygenation is often associated with serious complications.Small animal models have the advantages of low price,wide source,high flexibility and good reproducibility,and are an effective platform for evaluating strategies for prevention and treatment of ECMO complications.In recent years,more and more experimental studies have been conducted using small animal ECMO models.In this paper,the current status of the construction and application of small animal ECMO models at home and abroad is summarized,in order to optimize the related strategies of small animal ECMO model construction and promote the application and development of small animal ECMO models.

关 键 词：体外膜氧合 小动物模型 构建 应用 

分 类 号：R54[医药卫生—心血管疾病]