补体在高血压肾病发生发展中的作用  

Role of Complement in the Development of Hypertensive Nephropathy

作　　者：王忠丽[1] 张婷婷 王杏[3] 翟建龙 和丽丽[2] 左庆娟 马赛[5] 张国瑞 郭艺芳[2] WANG Zhongli;ZHANG Tingting;WANG Xing;ZHAI Jianlong;HE Lili;ZUO Qingjuan;MA Sai;ZHANG Guorui;GUO Yifang(Department of Physical Examination Center,Hebei General Hospital,Shijiazhuang 050000,China;Department of Geriatric Cardiology,Hebei General Hospital,Shijiazhuang 050000,China;Hebei Key Laboratory of Metabolic Diseases,Hebei General Hospital,Shijiazhuang 050000,China;Department of Cardiology,Hebei General Hospital,Shijiazhuang 050000,China;Department of Internal Medicine,Hebei General Hospital,Shijiazhuang 050000,China;Department of Cardiology,The Third Hospital of Shijiazhuang City Affiliated to Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院体检中心,石家庄050000 [2]河北省人民医院老年心脏科,石家庄050000 [3]河北省人民医院代谢性疾病重点实验室,石家庄050000 [4]河北省人民医院心血管内科,石家庄050000 [5]河北省人民医院内科,石家庄050000 [6]河北医科大学第三医院心血管内科,石家庄050051

出　　处：《中国循环杂志》2025年第3期308-312,共5页Chinese Circulation Journal

基　　金：河北省创新能力提升计划项目(199776249D)。

摘　　要：免疫炎症介导了高血压肾病的发生发展,补体系统作为先天免疫系统的重要组成部分,其异常激活在高血压肾病的发生发展中起着重要作用。补体抑制有望成为治疗高血压肾病的潜在策略。本文将总结回顾补体系统在高血压肾病发生发展中的相关研究及补体靶向药物治疗,为高血压肾病的临床诊治提供新的思路。Immunoinflammation mediates the development of hypertensive nephropathy,and aberrant activation of the complement system,an important component of the innate immune system,plays an important role in the development of hypertensive nephropathy.Complement inhibition is expected to be a potential strategy for the treatment of hypertensive nephropathy.In this article,we summarized and reviewed relevant studies on the complement system in the development of hypertensive nephropathy,and complement-targeted drug therapy,aiming to provide new ideas for clinicians on the clinical diagnosis and treatment of hypertensive nephropathy.

关 键 词：高血压肾病 补体 治疗 

分 类 号：R541.4[医药卫生—心血管疾病]