结肠炎微环境响应型聚合物药物递送系统在结肠炎治疗中的研究进展  

Research Progress of Colitis Microenvironment-Responsive Polymer Drug Delivery System in the Treatment of Colitis

作　　者：魏志刚 林玉红 王静安 徐山根 赵凯[1,2] WEI Zhigang;LIN Yuhong;WANG Jingan;XU Shangen;ZHAO Kai(Engineering Research Center of Agricultural Microbiology Technology,Ministry of Education&Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region&School of Life Sciences,Heilongjiang University,Harbin 150080,China;Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation,Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms,School of Life Sciences,Taizhou University,Taizhou 318000,China)

机构地区：[1]农业微生物技术教育部工程研究中心,黑龙江省寒区植物基因与生物发酵重点实验室,黑龙江大学生命科学学院,哈尔滨150080 [2]浙江省植物进化生态学与保护重点实验室,台州市生物医药与高端剂型重点实验室,台州学院生命科学学院,台州318000

出　　处：《医药导报》2025年第4期603-610,共8页Herald of Medicine

基　　金：国家自然科学基金资助项目(32302964);台州市科技计划资助项目(23gya02)。

摘　　要：聚合物作为常见的药物递送材料,具有制备方法简单、化学结构可调节和出色的生物相容性等优点,在许多疾病的响应递送方面,特别是在结肠疾病的药物递送中有广阔的研究和应用价值。利用聚合物的结构可调节的特点,目前已构建出基于pH响应、微生物酶响应、活性氧响应、生物黏附等递送策略的聚合物药物递送系统,在结肠炎治疗中展现出优异效果。该文综述了结肠炎微环境响应型聚合物药物递送系统在结肠炎治疗中的研究进展,并对其研究和应用前景进行讨论。As common drug delivery materials,polymers possess the advantages of a simple preparation method,adjustable chemical structure,and excellent biocompatibility.They are widely used in the responsive drug delivery for various diseases,especially in drug delivery of colon diseases.Utilizing the adjustable characteristics of polymers,drug delivery systems based on pH response,microbial enzyme response,reactive oxygen species response,and bio-adhesion have been constructed,showing excellent efficacy in the treatment of colitis.This article reviews the research progress of polymer-based targeted drug delivery systems in the treatment of colitis and discusses its research and application prospects.

关 键 词：聚合物 结肠炎微环境 刺激响应 药物递送系统 靶向治疗 

分 类 号：R97[医药卫生—药品] R574.62[医药卫生—药学]