松萝酸抗肿瘤作用研究进展  

Research Progress on Antitumor Effects of Usnic Acid

作　　者：胡珊珊 刘亚云 盛德乔[1] 杨轶 HU Shanshan;LIU Yayun;SHENG Deqiao;YANG Yi(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,College of Basic Medical Sciences,China Three Gorges University,Yichang 443002,China)

机构地区：[1]肿瘤微环境与免疫治疗湖北省重点实验室,三峡大学基础医学院,宜昌443002

出　　处：《医药导报》2025年第4期619-627,共9页Herald of Medicine

基　　金：2024年湖北省自然科学基金资助项目(2024AFB290);2021年肿瘤微环境与免疫治疗湖北省重点实验室开放课题(2021KZL02)。

摘　　要：松萝酸是一种地衣的次生代谢产物,因具有抗肿瘤、抗菌、抗病毒及抗炎等多种药理作用而被广泛应用于医药、膳食补充剂和日化产品(饲料、染料、食品、香水和化妆品)等领域。近年来研究发现,松萝酸可以通过诱导肿瘤细胞的凋亡和自噬、阻滞肿瘤细胞周期进程、抑制细胞的迁移与侵袭、调控miRNA表达等方面抑制多种肿瘤的发生与发展。此外,松萝酸能够与临床抗癌药物联用产生协同抗癌效应,经改造后得到的松萝酸类似物也表现出较好的抗肿瘤活性。该文围绕松萝酸的研究现状,从松萝酸的理化性质、抗肿瘤作用机制及其类似物的抗肿瘤作用等方面进行综述与展望。Usnic acid,a secondary metabolite derived from lichens,has been extensively utilized in pharmaceuticals,dietary supplements,and various daily chemical products,including feed,dye,food,perfume and cosmetics,due to its notable pharmacological effects,including anti-tumor,antibacterial,antiviral,and anti-inflammatory properties.Recent studies have shown that usnic acid can inhibit the occurrence and progression of various tumors through inducing apoptosis and autophagy,arresting cell cycle progression,inhibiting cell migration and invasion,and regulating the expression of microRNAs(miRNAs).Furthermore,usnic acid can be combined with clinical anticancer drugs to achieve synergistic anti-cancer effects.Additionally,modified usnic acid analogues also exhibit significant anti-tumor activity.This article will focus on the current research status of usnic acid,examining its physical and chemical properties,the mechanisms underlying its anti-tumor effects,and the anti-tumor activity of its analogues.

关 键 词：松萝酸 松萝酸类似物 抗肿瘤 

分 类 号：R932[医药卫生—生药学] R979.1[医药卫生—药学]