静脉用药调配中心配液机器人与传统人工配液质量对比探究  

Comparative Study on the Quality of Robotic and Manual Dispensing in Intravenous Admixture Service

作　　者：吴寿鹏 牛振东 肖斯婷 王琳 司延斌[1] 赵志刚[1] WU Shoupeng;NIU Zhendong;XIAO Siting;WANG Lin;SI Yanbin;ZHAO Zhigang(Department of Pharmacy,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Beijing Institute of Drug Testing,Beijing 102206,China)

机构地区：[1]首都医科大学附属北京天坛医院药学部,北京100070 [2]北京市药品检验研究院,北京102206

出　　处：《医药导报》2025年第4期668-672,共5页Herald of Medicine

摘　　要：目的对比智能调配机器人与传统人工在静脉用药调配中心(PIVAS)配液成品的质量,保证临床输液安全。方法在人工配液和机器人配液2种模式下,分别以奥美拉唑和氨溴索为主药,5%葡萄糖注射液和0.9%氯化钠注射液为溶媒混配后的成品液为对象,评估了多项质量指标,包括药品残留量和不溶微粒数等。结果机器人配液和人工配液模式下药品残留量在5%以内,不溶微粒远小于限度、pH值符合人体输液范围,内毒素和无菌培养均为阴性结果,差异无统计学意义(P>0.05)。结论机器人配液模式下配液成品液质量有保障,与传统人工配液质量无显著差异,为PIVAS应用机器人配液提供成品液质量的可靠保障。Objective To compare the quality of liquids dispensed by intelligent dispensing robot and traditional manual in PIVAS,to ensure the safety of clinical infusion.Methods Using omeprazole and ambroxol as the main drugs and 5%glucose injection and 0.9%sodium chloride solution as the solvent,a number of quality indexes including drug residues and the number of insoluble particles were evaluated in the two modes of manual and robotic dispensing,respectively.Results Under the robot dispensing mode and manual dispensing mode,the residual amount of drugs was less than 5%,the insoluble particles were far less than the limit,the pH value was in line with the human infusion range,and the endotoxin and aseptic culture were negative results,with no statistical significance(P>0.05).Conclusions The quality of liquid dispensed under the robotic dispensing mode is guaranteed,and there is no significant difference in the quality of liquid dispensed with the traditional manual dispensing mode,which provides a reliable guarantee for the large-scale application of robotic dispensing in intravenous admixture service.

关 键 词：静脉用药调配 机器人配液 人工配液 质量分析 

分 类 号：R97[医药卫生—药品]