参麦注射液对冠脉造影后急性肾损伤炎症因子的影响  

Effect of Shenmai injection on inflammatory factors in acute kidneyinjury after coronary angiography

作　　者：崔冰[1] 赵安社[2] 陈鹏[2] 李海涛 CUI Bing;ZHAO Anshe;CHEN Peng;LI Haitao(Blood Purification Center,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450000,China;Department of Cardiovascular Medicine,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学第一附属医院血液净化中心,河南郑州450000 [2]河南中医药大学第一附属医院心内科,河南郑州450000

出　　处：《现代医药卫生》2025年第3期621-624,共4页Journal of Modern Medicine & Health

基　　金：河南省中医药科学研究专项课题项目(20-21ZY2096)。

摘　　要：目的 探讨参麦注射液对冠状动脉造影后急性肾损伤炎症因子的影响。方法 选取2021年11月至2024年8月该院心内科收治的80例拟行冠状动脉造影术的患者作为研究对象,将其随机分为观察组和对照组,各40例。2组患者均给予常规对症治疗,观察组患者在此基础上给予参麦注射液干预,2组患者进行冠状动脉造影后观察3 d。比较2组患者冠状动脉造影后急性肾损伤发生率,手术前后肾功能指标[尿素氮(BUN)、血肌酐(Scr)、胱抑素C(CysC)],肾脏血流动力学指标[收缩期峰值流速(PSFV)、舒张期末血流速度(EDFV)、阻力指数(RI)],炎症指标[白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)]。结果 观察组患者冠状动脉造影后急性肾损伤发生率[12.5%(5/40)]低于对照组[40.0%(16/40)],差异有统计学意义(χ^(2)=7.812,P=0.005)。术后3 d,观察组患者PSFV、EDFV水平[(33.61±4.39)、(12.39±1.43)cm/s]均高于对照组[(29.23±4.51)、(9.46±1.67)cm/s],差异均有统计学意义(P<0.05)。术后3 d,观察组患者IL-6、IL-8、TNF-α水平[(24.61±1.53)、(6.31±0.82)、(6.84±1.24)pg/mL]均低于对照组[(26.37±1.82)、(8.14±1.13)、(8.17±1.30)pg/mL],差异均有统计学意义(P<0.05)。结论 参麦注射液可降低冠状动脉造影后急性肾损伤发生率,同时改善患者造影术后肾脏血流动力学指标,促进患者肾功能恢复,减轻机体炎症反应。Objective To investigate the effect of Shenmai injection on inflammatory factors in acute kidney injury(AKI)after coronary angiography.Methods A total of 80 patients who were scheduled for coronary angiography at the Department of Cardiovascular Medicine,the hospital from November 2021 to August 2024 were selected as the study subjects.They were randomly divided into an observation group and a control group,with 40 cases in each group.Both groups received conventional symptomatic treatment.The observation group was additionally treated with Shenmai injection,and both groups were observed for three days after coronary angiography.The incidence of acute kidney injury after coronary angiography,renal function indicators[blood urea nitrogen(BUN),serum creatinine(Scr),cystatin C(CysC)],renal hemodynamic parameters[peak systolic flow velocity(PSFV),end-diastolic flow velocity(EDFV),resistance index(RI)],and inflammatory markers[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results The incidence of acute kidney injury after coronary angiography in the observation group[12.5%(5/40)]was significantly lower than that in the control group[40.0%(16/40)],with a statistically significant difference(χ^(2)=7.812,P=0.005).The PSFV and EDFV levels in the observation group on the 3rd day after surgery[(33.61±4.39),(12.39±1.43)cm/s]were higher than those in the control group[(29.23±4.51),(9.46±1.67)cm/s],with statistically significant differences(P<0.05).The levels of IL-6,IL-8,and TNF-αin the observation group on the 3rd day after surgery[(24.61±1.53),(6.31±0.82),(6.84±1.24)pg/mL]were lower than those in the control group[(26.37±1.82),(8.14±1.13),(8.17±1.30)pg/mL],with statistically significant differences(P<0.05).Conclusion Shenmai injection can reduce the incidence of acute kidney injury after coronary angiography,improve renal hemodynamic parameters after angiography,promote the recovery of renal function,and alleviate the inflammatory response in the bo

关 键 词：参麦注射液 血管造影术 造影剂 急性肾损伤 炎症因子 

分 类 号：R286[医药卫生—中药学]