妊娠期糖尿病代谢记忆的研究进展  

Research progress of metabolic memory in gestational diabetes mellitus

作　　者：张静[1] 刘嘉[1] ZHANG Jing;LIU Jia(Department of Gynaecology and Obstetrics,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510632,China)

机构地区：[1]暨南大学附属第一医院妇产科,广东广州510632

出　　处：《现代医药卫生》2025年第3期748-752,共5页Journal of Modern Medicine & Health

基　　金：广东省广州市科技计划项目(2024A03J1115)。

摘　　要：妊娠期糖尿病(GDM)是妊娠期最常见的代谢性疾病,严重危害母婴健康。临床控制血糖可减少不良妊娠结局的发生,但不能有效降低GDM患者及其后代日后罹患心脏病、糖尿病、中风等疾病的风险,代谢记忆与之密切相关。因此,阻断GDM代谢记忆可能成为将来干预GDM远期并发症的重要策略和手段。该文从GDM代谢记忆的发生机制及预测、预防等方面进行了综述,旨在为后期通过全生命周期管理阻断GDM代谢记忆的发生、发展提供新思路。Gestational diabetes mellitus(GDM)is the most common metabolic disorder during pregnancy that poses significant risks to both maternal and fetal health.Clinical control of blood glucose levels can reduce the occurrence of adverse pregnancy outcomes,but it can not effectively reduce the risk of heart disease,diabetes,stroke and other diseases of GDM patients and their offspring in the future,and metabolic memory is closely related to it.Consequently,interrupting the metabolic memory of GDM may become an important strategy and means to intervene the long-term complications of GDM in the future.This article reviewed the mechanism,prediction and prevention of GDM metabolic memory,aiming at providing new ideas for blocking the occurrence and development of GDM metabolic memory through life cycle management in the later period.

关 键 词：妊娠期糖尿病 代谢记忆 表观遗传学 DNA甲基化 综述 

分 类 号：R714.25[医药卫生—妇产科学]