不同来源间充质干细胞对自然杀伤细胞的影响  

Effects of mesenchymal stem cells from different sources on natural killer cells

作　　者：刘秀丽 王洪波[1] 谢鹏[1] 江明[1] LIU Xiuli;WANG Hongbo;XIE Peng;JIANG Ming(Department of Hematology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆医科大学第一附属医院血液病科,新疆乌鲁木齐830000

出　　处：《现代医药卫生》2025年第3期776-778,共3页Journal of Modern Medicine & Health

摘　　要：间充质干细胞(MSC)抑制T淋巴细胞的能力促使其用于移植物抗宿主病的治疗。由于MSC还能调节自然杀伤(NK)细胞的活性,而NK细胞在移植物抗白血病反应中具有重要作用。因此,在移植后给予间充质干细胞治疗或预防移植物抗宿主病的同时也可能会影响NK细胞的抗白血病作用。MSC可从多种来源扩增,尤其是骨髓和脂肪,但细胞来源是否对其免疫调节能力产生影响尚不清楚。该文综述了不同来源MSC对NK细胞的免疫调节作用,以确定使用何种来源的MSC更有利于保护NK细胞活性,从而保护移植物抗白血病效应。The ability of mesenchymal stem cells(MSCs)to inhibit T lymphocytes promotes their use in the treatment of graft-versus-host disease.Since MSC can also regulate the activity of natural killer(NK)cells,NK cells play an important role in graft-versus-leukemia response.Therefore,the treatment of mesenchymal stem cells after transplantation or the prevention of graft-versus-host disease may also affect the anti-leukemia effect of NK cells.MSC can be amplified from a variety of sources,especially bone marrow and fat,but it is not clear whether the cell source has an effect on its immune regulation ability.This article reviews the immunomodulatory effects of MSC from different sources on NK cells to determine which source of MSC is more conducive to protecting NK cell activity and thus protecting graft anti-leukemia effects.

关 键 词：间充质干细胞 自然杀伤细胞 综述 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]