Sea cucumber derived sulfated sterols alter glucose metabolism by promoting gluconeogenesis and reducing glycogenesis in healthy mice  

作　　者：Shanyun Yu Teng Wang Yingcai Zhao Xiaoyue Li Changhu Xue Yuming Wang Tiantian Zhang 

机构地区：[1]SKL of Marine Food Processing&Safety Control,College of Food Science and Engineering,Ocean University of China,Qingdao 266404,China [2]Sanya Institute of Oceanography,Ocean University of China,Sanya 572024,China

出　　处：《Food Science and Human Wellness》2025年第2期719-728,共10页食品科学与人类健康(英文)

基　　金：supported by National Natural Science Foundation of China(32072145)。

摘　　要：Sea cucumber derived sulfated sterols significantly ameliorated insulin resistance and decreased lipid accumulation compared to plant sterols.Interestingly,our recent study found that intervention with sea cucumber sulfated sterols could significantly increase blood glucose levels of healthy mice in the presence of glucose,while cholesterol sulfate,as one of sulfated sterols,did not have the same effect.However,the exact mechanism of sulfated sterols on glucose metabolism is still unknown.In the present study,we investigated the potential mechanism by which sulfated sterols influenced blood glucose homeostasis in healthy mice.Results showed that intervention with sea cucumber sulfated sterols did not affect the levels of hormones related to glucose metabolism,while led to a significant decrease in the synthesis of liver glycogen and muscle glycogen.Besides,the expression of proteins associated with the promotion of gluconeogenesis dramatically increased in the mice intervened with sea cucumber sulfated sterols.These findings suggested that sea cucumber sulfated sterols might change blood glucose metabolism in healthy mice by reducing glycogenesis and promoting gluconeogenesis.

关 键 词：Sea cucumber Sulfated sterols Cholesterol sulfate Blood glucose Metabolism 

分 类 号：O62[理学—有机化学]