Exploiting neonatal host-bifidobacteria interactions to promote intestinal pathogen tolerance and barrier function:Bifidobacterium longum subsp.infantis outperforms Bifidobacterium adolescentis in anti-Salmonella activity and maintenance of intestinal hom  

作　　者：Chunxiu Lin Shunhe Wang Min Guo Wentian Li Jiayin Qiu Yonghua Zhou Hao Zhang Wei Chen Gang Wang 

机构地区：[1]State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China [2]School of Food Science and Technology,Jiangnan University,Wuxi 214122,China [3]Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention,Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology,Jiangsu Institute of Parasitic Diseases,Wuxi 214064,China [4]National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China [5]Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch,Wuxi 214122,China [6](Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China

出　　处：《Food Science and Human Wellness》2025年第4期1343-1359,共17页食品科学与人类健康(英文)

基　　金：supported by the National Natural Science Foundation of China(32021005,32272332);the Fundamental Research Funds for the Central Universities(JUSRP622020,JUSRP51501);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province;Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_2391)。

摘　　要：Bifidobacterium longum subsp.infantis and Bifidobacterium adolescentis play important roles in the guts of infants and adolescents,respectively.In this study,using a neonatal rat model,we compared the protective effects of these 2 bifidobacterial species against Salmonella infection.The results demonstrated that B.longum subsp.infantis was more effective than B.adolescentis in alleviating the severity of infection in newborn rats exposed to Salmonella enterica serovar Typhimurium strain SL1344.B.longum subsp.infantis attenuated intestinal inflammation and mucosal damage induced by Salmonella infection,as well as protecting intestinal nerves and intestinal barrier function through TLR4/My D88 signalling.B.longum subsp.infantis also displayed the potential to modulate gut metabolites by promoting the biosynthesis of unsaturated fatty acids(arachidonic acid,eicosapentaenoic acid andα-linolenic acid)and purine metabolism(guanine,adenine,inosine and adenosine),thereby regulating metabolic disturbances.Additionally,the benefits of B.longum subsp.infantis were also observed in the liver,spleen and brain,improving nerve reflexes and suppressing hepatosplenomegaly.Overall,these findings provide novel insights into the prevention and treatment of gutrelated diseases in newborns,highlighting the potentially significant role of B.longum subsp.infantis in clinical applications.

关 键 词：Salmonella infection Bifidobacterium longum subsp.infantis Bifidobacterium adolescentis NEWBORN Intestinal inflammation 

分 类 号：R371[医药卫生—病原生物学]