Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content:a randomized controlled efficacy trial in rural Burkina Faso  

作　　者：Giles T.Hanley-Cook Yuri Bastos-Moreira Dries S.Martens Trenton Dailey-Chwalibóg Laeticia Celine Toe Brenda de Kok Lionel OIivier Ouédraogo Alemayehu Argaw Kokeb Tesfamariam Patrick Kolsteren Lieven Huybregts Tim S.Nawrot Sarah De Saeger Marthe De Boevre Carl Lachat 

机构地区：[1]Department of Food Technology,Safety and Health,Faculty of Bioscience Engineering,Ghent University,Ghent 9000,Belgium [2]Center of Excellence in Mycotoxicology and Public Health,MYTOXSOUTH®Coordination Unit,Faculty of Pharmaceutical Sciences,Ghent University,Ghent 9000,Belgium [3]Centre for Environmental Sciences,Hasselt University,Diepenbeek 3590,Belgium [4]UnitéNutrition et Maladies Métaboliques,Institut de Recherche en Sciences de la Santé(IRSS),Bobo-Dioulasso,01 BP 545 Burkina Faso [5]Centre Muraz,Bobo-Dioulasso,01 BP 390 Burkina Faso [6]Nutrition,Diets,and Health Unit,Department of Food and Nutrition Policy,International Food Policy Research Institute(IFPRI),Washington DC 20005,USA [7]Department of Public Health&Primary Care,University of Leuven,Leuven 3000,Belgium [8]Department of Biotechnology and Food Technology,Faculty of Science,University of Johannesburg,Doornfontein Campus,Gauteng 2028,South Africa

出　　处：《Food Science and Human Wellness》2025年第4期1387-1397,共11页食品科学与人类健康(英文)

基　　金：supported by the Bill&Melinda Gates Foundation(OPP1175213);supported by the Research Foundation Flanders(12X9620N and 12X9623N);the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(946192,HUMYCO)。

摘　　要：Background:Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes.The effect on markers of health and disease,such as offspring telomere length(TL)and mitochondrial DNA content(mtDNAc)is unknown.Objectives:We assessed the efficacy of maternal multiple micronutrient(MMN)-fortified balanced-energy protein(BEP)and iron-folic acid(IFA)supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome.Design:We conducted a randomized controlled trial in rural Burkina Faso,among pregnant females(15-40 years old)enrolled at<21 weeks of gestation.Mothers received either MMN-fortified BEP and IFA(intervention)or IFA only(control)throughout pregnancy.Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants,respectively.Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction.Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.Results:We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL[β=-0.010(95%CI:-0.057,0.036);P=0.662]or mtDNAc[β=0.065(95%CI:-0.203,0.073);P=0.354],as compared to an IFA tablet alone.These findings were confirmed(P>0.05)by adjusting the regression models for potential prognostic factors of study outcomes at enrollment.Exploratory analyses indicated higher,but non-significantly different mtDNAc among children born either small-for-gestational age,low birthweight,or preterm.Conclusion:Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.

关 键 词：Balanced-energy protein Burkina Faso Iron-folic acid Mitochondrial DNA Multiple micronutrients Randomized controlled trial Telomere length 

分 类 号：R722.1[医药卫生—儿科] TS201.4[医药卫生—临床医学]