线粒体自噬在动脉粥样硬化中作用的研究进展  

Progress in role of mitophagy in atherosclerosis

作　　者：郑标 王琼 肖玉波 谢远杰 莫中成 ZHENG Biao;WANG Qiong;XIAO Yubo;XIE YuanJie;MO Zhongcheng(Guangxi Key Laboratory of Diabetic Systems Medicine,Department of Histology and Embryology,Guilin Medical University,Guilin 541199,China;School of Public Health and Laboratory Medicine,Hunan University of Medicine,Huaihua 418000,China)

机构地区：[1]广西糖尿病系统医学重点实验室,桂林医学院组织学与胚胎学教研室,广西桂林541199 [2]湖南医药学院公共卫生与检验医学院,湖南怀化418000

出　　处：《中国病理生理杂志》2025年第3期585-592,共8页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82460092,No.82060091);广西科技厅中央引导地方科技发展资金项目(桂科ZY21195024号);广西研究生教育创新计划项目(No.YCSW2023425)。

摘　　要：线粒体自噬作为一种特殊的选择性自噬,通过调控细胞脂质代谢、炎症反应、氧化应激等过程参与动脉粥样硬化的发生发展。近年来的研究发现,许多药物及中草药成分通过调控巨噬细胞、血管内皮细胞及血管平滑肌细胞的线粒体自噬,影响动脉粥样硬化的进程。本文围绕线粒体自噬调控细胞功能进而影响动脉粥样硬化进展的分子机制,总结了近年来通过靶向调控线粒体自噬抗动脉粥样硬化的治疗药物相关研究进展,为寻求靶向调控线粒体自噬改善动脉粥样硬化的防治新策略提供新的思路。Mitophagy,a special form of selective autophagy,plays a significant role in the pathogenesis of atherosclerosis by regulating cellular lipid metabolism,inflammation,and oxidative stress.However,its regulatory mech-anism is complex and has not been fully elucidated.Notably,many drugs and herbal ingredients exhibit anti-atherosclerot-ic effects by modulating mitophagy in macrophages,vascular endothelial cells,and vascular smooth muscle cells,offering potential new avenues for the prevention and treatment of atherosclerosis.In this article,we review the role of mitophagy in regulating cellular functions and the progression of atherosclerosis,as well as summarize potential therapeutic drugs that may contribute to anti-atherosclerosis by modulating mitophagy.Our aim is to provide a new literature basis for further ex-ploration of the role of mitophagy in atherosclerosis.

关 键 词：动脉粥样硬化 线粒体自噬 巨噬细胞 血管内皮细胞 血管平滑肌细胞 

分 类 号：R543.5[医药卫生—心血管疾病] R363[医药卫生—内科学] Q255[医药卫生—临床医学]