High-performance Flow Chemistry Platform for Scalable Continuous Synthesis of Branched Block Copolymers with Precise Chain Structures  

作　　者：Bang-Bang Wang Zhuang Zhang Jing-Tao Wang Li Pan Yue-Sheng Li Dong-Po Song 

机构地区：[1]Tianjin Key Laboratory of Composite and Functional Materials,School of Materials Science and Engineering,Tianjin University,Tianjin 300350,China [2]School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China

出　　处：《Chinese Journal of Polymer Science》2025年第3期457-467,共11页高分子科学(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(No.22071176)。

摘　　要：Cutting-edge research has primarily focused on flow synthesis of linear block copolymers,lacking the ability for manipulating chain architectures for more extensive applications.Herein,we develop a flow chemistry platform for the continuous microflow synthesis of bottlebrush block copolymers(BBCPs)using a grafting-through method.This involves performing ring-opening metathesis polymerization(ROMP)of two different macromonomers within two microfluidic reactors connected in series.The microflow environment allows for complete monomer conversion within a few tens of seconds,benefiting from the superior mixing efficiency achieved in Z-shaped channels as indicated by both theoretical simulations and experimental results.Consequently,a library of well-defined BBCPs of up to 528 distinct samples can be produced within one day through automation of the continuous procedure,while keeping precise control on degree of polymerization(DP<4)and polydispersity indices(PDI<1.2).The synthetic method is generally applicable to different macromonomers with different compositions and contour lengths,yielding libraries of branched block copolymers with great diversity in physiochemical properties and chain architectures.This work presents a powerful platform for high-throughput production of branched copolymers,significantly lowering the costs of the materials for real applications.

关 键 词：Continuous flow synthesis Ring opening metathesis polymerization Branched copolymer 

分 类 号：O63[理学—高分子化学]