光固化3D打印高分子微针的研究进展  

Progress on Research of Vat Polymerization 3D Printed Microneedles

作　　者：童方正 刘思颖 钱妍 张骏 张克勤[1,2,3] Fangzheng Tong;Siying Liu;Yan Qian;Jun Zhang;Keqin Zhang(College of Textiles and Clothing Engineering,Soochow University,Suzhou 215021,China;National Engineering Laboratory for Modern Silk,Soochow University,Suzhou 215123,China;China National Textile and Apparel Council Key Laboratory of Silk Functional Materials and Technology,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学纺织与服装工程学院,江苏苏州215021 [2]苏州大学现代丝绸国家工程实验室,江苏苏州215123 [3]苏州大学纺织行业丝绸功能材料与技术重点实验室,江苏苏州215123

出　　处：《高分子材料科学与工程》2025年第1期154-164,共11页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(51873134,52303043);江苏省高校自然科学研究项目面上项目(23KJB430031);江苏省自然科学基金资助项目(BK20211317);江苏省丝绸工程重点实验室开放课题(KJS2168);江苏高校优势学科建设工程项目(PAPD)。

摘　　要：高分子微针凭借其灵活可调的分子网络结构,在透皮给药、皮肤修复及生物传感等领域得到了广泛应用。与传统的倒模法制备微针相比,光固化3D打印高分子微针在精细设计和快速制备方面具有明显优势,其发展前景令人瞩目。文中介绍了高分子微针的基本分类、制备方法以及适用于光固化3D打印的高分子微针材料。此外,针对光固化3D打印高分子微针精度和刺入强度不足等问题,从打印墨水、成型参数、微针模型设计和后处理4个方面对其进行了总结,并探讨了目前光固化3D打印高分子微针的应用趋势,最后对其未来的发展前景进行了展望。Polymer microneedles are widely used in transdermal drug delivery,skin regeneration,and biosensing due to their flexible and adjustable molecular network structure.Compared with the traditional reverse molding method for preparing microneedles,vat polymerization 3D printed polymer microneedles have significant advantages in personalized design and rapid preparation,and have enormous development potential.This article introduced the basic classification,preparation methods,and polymer microneedle materials suitable for vat polymerization 3D printing of polymer microneedles.In addition,this article summarized the issues of insufficient precision and penetration strength of polymer microneedles in vat polymerization 3D printing from four aspects:printing ink,molding parameters,microneedle model design,and post-processing.It also summarized the current application trends of polymer microneedles in vat polymerization 3D printing,and finally looked forward to their future development prospects.

关 键 词：光固化3D打印 高分子微针 精度 强度 

分 类 号：TP391.73[自动化与计算机技术—计算机应用技术]