基于聚丙烯酸纳米复合材料的制备及其产后大出血的栓塞性能  

Preparation of nanocomposites based on polyacrylic acid and study on their embolic properties for postpartum hemorrhage

作　　者：陶诗 缪昭华 查正宝 TAO Shi;MIAO Zhaohua;ZHA Zhengbao(School of Food and Biological Engineering,Hefei University of Technology,Hefei 230009,China)

机构地区：[1]合肥工业大学食品与生物工程学院,合肥230009

出　　处：《复合材料学报》2025年第2期1081-1091,共11页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(52272275)。

摘　　要：产后出血(Postpartum hemorrhag,PPH)是一种严重的产科并发症,死亡率占所有产科并发症的25%。经导管动脉栓塞术(Transcatheter arterial embolization,TAE)已被证明能快速有效地控制顽固性产后出血。明胶海绵颗粒栓塞剂(Gelatin)作为PPH常用的介入栓塞剂,但往往很难成功地完全阻塞受伤的血管,因此在控制活动性出血如假性动脉瘤的表现不尽人意。由聚丙烯酸(Polyacrylic acid,PAA)、二维层状双氢氧化物(Layered double hydroxide,LDH)和聚乙二醇(Polyethylene glycol,PEG200)为原料的液体栓塞剂(PAA-LDH@PEG200)遇水可迅速固化形成水凝胶实现血管完全地闭塞。在体外闭塞模型中,该纳米复合材料PAA-LDH@PEG200在不同直径的管道中移位压力最高达150 kPa,远高于Gelatin闭塞导致的移位压力。此外,PAA-LDH@PEG200表现出良好的生物相容性和体内外可生物降解性。结果表明:所制备的液体栓塞剂有望替代明胶海绵颗粒成为产后大出血治疗的新一代栓塞剂。Postpartum hemorrhage(PPH)is a significant obstetric complication,representing 25%of all obstetric complications.Transcatheter arterial embolization(TAE)has been proven to be a rapid and effective method for controlling intractable postpartum hemorrhage.Gelatin sponge embolic agent(Gelatin)is a commonly used interventional embolic agent for PPH.However,it is often challenging to completely block the injured blood vessel,which can lead to inadequate control of active bleeding,such as pseudoaneurysms.The liquid embolic agent(PAA-LDH@PEG200),which comprises polyacrylic acid(PAA),two-dimensional layered double hydroxide(LDH),and polyethylene glycol 200(PEG200),can rapidly solidify into a hydrogel to achieve complete vascular occlusion.In the in vitro occlusion model,the nanocomposite PAA-LDH@PEG200 exhibits a displacement pressure of up to 150 kPa in pipes of varying diameters,significantly surpassing the pressure caused by Gelatin occlusion.In addition,PAA-LDH@PEG200 has shown good biocompatibility and biodegradability in vivo and in vitro.The results indicate that the developed liquid embolic agent is poised to replace gelatin sponge particles as a next-generation embolic agent for treating postpartum hemorrhage.

关 键 词：生物医药 产后出血 经导管动脉栓塞术 聚丙烯酸 液体栓塞剂 纳米复合材料 

分 类 号：R714.46[医药卫生—妇产科学] TQ317.3[医药卫生—临床医学] TB332[化学工程—高聚物工业]