Hedgehog信号通路在动物卵巢卵泡发育和类固醇生成中的调控作用  

The Regulatory Function of the Hedgehog Signaling Pathway in Follicle Development and Steroidogenesis of Animal Ovary

作　　者：灭列·马达尼牙提 孙萌 褚瑰燕[1] MIELIE·Madaniyati;SUN Meng;CHU Guiyan(College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China)

机构地区：[1]西北农林科技大学动物科技学院,杨凌712100

出　　处：《畜牧兽医学报》2025年第3期969-978,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金面上项目(32272849)。

摘　　要：Hedgehog(HH)信号通路是参与胚胎形成的关键途径之一,它在从果蝇到人类的进化过程中广泛分布且保持高度保守性,对多种器官的发育起到了至关重要的作用。研究指出,HH信号通路在卵巢卵泡的生长、颗粒细胞的增殖、卵母细胞的成熟、类固醇激素的合成以及排卵过程中扮演着重要的调节角色。本文基于现有研究成果,详细回顾了HH信号通路在卵巢卵泡生长、卵母细胞成熟、排卵以及类固醇激素合成中的调控功能,并概述了由于HH信号通路异常导致生殖能力下降的几种卵巢疾病的最新研究动态,旨在为提升雌性繁殖能力及卵巢疾病的治疗提供理论支持。The Hedgehog(HH)signaling pathway is one of the key pathways involved in embryogenesis,widely distributed and highly conserved throughout the evolutionary process from fruit flies to humans,playing a crucial role in the development of various organs.Studies have indicated that the HH signaling pathway plays an important regulatory role in the growth of ovarian follicles,proliferation of granulosa cells,maturation of oocytes,synthesis of steroid hormones,and process of ovulation.Based on the existing research findings,this article provides a detailed review of the regulatory functions of the HH signaling pathway in the growth of ovarian follicles,maturation of oocytes,ovulation,and synthesis of steroid hormones,as well as an overview of the latest research trends on several ovarian diseases that lead to a decline in fertility due to abnormalities in the HH signaling pathway,aiming to provide theoretical support for enhancing female reproductive capacity and the treatment of ovarian diseases.

关 键 词：HEDGEHOG信号通路 卵巢 生殖能力 卵泡发育 类固醇生成 

分 类 号：S814.1[农业科学—畜牧学] Q492.5[农业科学—畜牧兽医]