β-防御素的生物学特性及其在调控动物肠道屏障中的研究进展  

Research Progress on Biological Characteristics ofβ-defensins and Their Roles in Regulating Intestinal Barrier in Animals

作　　者：王卓 赵雨薇 屠焰[1] 刁其玉[1] 崔凯[1] WANG Zhuo;ZHAO Yuwei;TU Yan;DIAO Qiyu;CUI Kai(Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs,Institute of Feed Research of Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]中国农业科学院饲料研究所、农业农村部饲料生物技术重点实验室,北京100081

出　　处：《畜牧兽医学报》2025年第3期995-1005,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：“科技兴蒙”合作引导项目(2021CG0024);国家自然科学基金面上项目(32172764)。

摘　　要：肠道黏膜屏障是阻止外来病原性物质入侵的第一道防线,其完整性对维持肠道健康至关重要。β-防御素是广泛分布于哺乳动物上皮细胞的小分子多肽,具有抗微生物、抗肿瘤、抗炎及免疫调节等生物学特性,且抗菌广谱、分子量小、不易产生耐药性。β-防御素可以通过调节肠道菌群、肠上皮细胞紧密连接表达、肠上皮细胞抑菌物质的分泌以及肠黏膜免疫作用从而调控肠道屏障功能,维护肠道内环境的稳态。本文就β-防御素的生物学特性及作用机制、β-防御素在调控动物肠道屏障上的作用、饲料添加剂对肠道β-防御素的调节作用三大方面进行综述,以期为β-防御素在动物肠道中的应用提供参考。The intestinal mucosal barrier is the first line of defense against the invasion of foreign pathogenic substances,and its integrity is essential to maintain intestinal health.β-defensins are small molecular peptides widely distributed in mammalian epithelial cells.They have biological properties such as antimicrobial,anti-tumor,anti-inflammatory and immunomodulatory properties,and have a broad spectrum of antimicrobial activity,small molecular weight,and are not prone to drug-resistant.β-defensins can regulate intestinal barrier function by regulating intestinal flora,the expression of tight junction of intestinal epithelial cells,the secretion of bacteriostatic substances in intestinal epithelial cells,and the immune function of intestinal mucosa,thus maintaining the homeostasis of the intestinal environment.In this paper,the biological characteristics of β-defensins and its function mechanism,the regulation ofβ-defensins on animal intestinal barrier function,regulatory effect of feed additive onβ-defensins were reviewed,in order to provide reference for its application in animal intestines.

关 键 词：Β-防御素 生物学特性 畜禽 肠道屏障 

分 类 号：S852.2[农业科学—基础兽医学]