胆汁酸调控动物肠道健康的作用及机制研究进展  

Advances in Effect and Mechanism of Bile Acids Regulating Animal Intestinal Health

作　　者：王馨怡 姚军虎[1] 张霞 张俊 WANG Xinyi;YAO Junhu;ZHANG Xia;ZHANG Jun(College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China;College of Veterinary Medicine,Northwest A&F University,Yangling 712100,China;National Center of Technology Innovation for Dairy,Hohhot 010100,China)

机构地区：[1]西北农林科技大学动物科技学院,杨凌712100 [2]西北农林科技大学动物医学院,杨凌712100 [3]国家乳业技术创新中心,呼和浩特010100

出　　处：《畜牧兽医学报》2025年第3期1006-1018,共13页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家乳业技术创新中心(2024-JSGG-021);宁夏回族自治区重点研发计划(2024BBF01006);国家自然科学基金(32102570)。

摘　　要：胆汁酸是胆固醇代谢的重要产物,分泌到肠道中的胆汁酸可通过杀菌抗炎和信号传导等发挥改善肠道结构形态、维护肠道屏障完整、调节肠道微生物区系平衡以及增强黏膜免疫等功能,利于肠道内环境稳态,促进动物正常生长和提高生产性能。本文围绕胆汁酸的功能,系统综述其对动物肠道形态、黏液屏障、微生物屏障和黏膜免疫的调节作用及机制,以期为利用胆汁酸调节肠道健康提供理论依据。Bile acids are important products of cholesterol metabolites,and the bile acids secreted into the intestine can improve the structure and morphology of the intestine,maintain the integrity of the intestinal barrier,regulate the balance of the intestinal microflora,and enhance the functions of mucosal immunity through bactericidal,anti-inflammatory and signal transduction,which is conducive to the homeostasis of the intestinal environment,promotes the normal growth of animals and improves the production performance.This paper systematically elaborate the regulatory effects and mechanisms of bile acids on intestinal morphology,mucus barrier,microbial barrier and mucosal immunity in animals,in order to provide a theoretical basis for the use of bile acids to regulate intestinal health.

关 键 词：胆汁酸 肠道形态 微生物屏障 肠道健康 

分 类 号：S852.2[农业科学—基础兽医学]