肠道共生生物对肠道干细胞的调节机制研究进展  

Research Progress on the Regulatory Mechanisms of Intestinal Commensal Organisms on Intestinal Stem Cells

作　　者：丁莹莹 张嘉芸 唐龙轩 张少华[1] 郭小腊 蒲丽霞 牟文杰 王帅[1] DING Yingying;ZHANG Jiayun;TANG Longxuan;ZHANG Shaohua;GUO Xiaola;PU Lixia;MOU Wenjie;WANG Shuai(State Key Laboratory for Animal Disease Control and Prevention,College of Veterinary Medicine,Lanzhou University,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730000,China)

机构地区：[1]中国农业科学院兰州兽医研究所、兰州大学动物医学与生物安全学院动物疫病防控全国重点实验室,兰州730000

出　　处：《畜牧兽医学报》2025年第3期1019-1026,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：“十四五”国家重点研发计划项目(2023YFD1801700);甘肃省科技重大专项(22ZD6NA001)。

摘　　要：肠道干细胞(intestinal stem cells,ISCs)在维持肠道稳态中起重要作用。已有研究表明,肠道共生生物(如微生物和寄生虫及其代谢产物)对宿主的干细胞调节至关重要,可通过直接或间接作用影响肠道干细胞的更新分化。本文重点阐述了肠道菌群和蠕虫及其代谢产物对ISCs的影响,并侧重总结了相关的细菌、代谢产物等对ISCs增殖分化的研究进展,旨在为未来肠道损伤治疗提供新的思路。Intestinal stem cells(ISCs)are vital for maintaining intestinal homeostasis.Research indicates that intestinal commensal organisms,including microorganisms and parasites,along with their metabolites,play a crucial role in regulating host stem cells.These organisms can influence the renewal and differentiation of ISCs through direct or indirect mechanisms.This article delves into the impact of intestinal microbiota,worms,and their metabolites on ISCs,and provides an overview of current research on how related bacteria and metabolites affect the proliferation and differentiation of ISCs.The goal of this review is to offer innovative insights for potential future treatments of intestinal injuries.

关 键 词：肠道菌群 肠道蠕虫 肠道干细胞 

分 类 号：S852.2[农业科学—基础兽医学]