猪流行性腹泻疫苗研究进展  

Research Progress of Porcine Epidemic Diarrhea Vaccine for Pigs

作　　者：邬沛伶 李依璇 王浩杰 李亚菲 刘绍蒙 刘青芸 王湘如[1,2] WU Peiling;LI Yixuan;WANG Haojie;LI Yafei;LIU Shaomeng;LIU Qingyun;WANG Xiangru(The Cooperative lmnovation Center for Sustainable Pig Production,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China;State Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学动物医学院生猪健康养殖协同创新中心,武汉430070 [2]华中农业大学动物医学院农业微生物资源发掘与利用全国重点实验室,武汉430070

出　　处：《畜牧兽医学报》2025年第3期1042-1058,共17页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金优秀青年科学基金(32122086);国家自然科学基金青年科学基金(32402921)。

摘　　要：猪流行性腹泻(porcine epidemic diarrhea,PED)是由猪流行性腹泻病毒(porcine epidemic diarrhea virus,PEDV)引起的一种传染性肠道疾病,可造成猪群暴发腹泻和初生仔猪大量死亡。2010年,高致病性的PEDV变异毒株出现并在全球范围内传播,已成为当前猪腹泻病的主要病原之一,对全球养猪业造成巨大损失。疫苗免疫是防控PED的最主要措施。现有PED商品化疫苗以传统灭活疫苗和弱毒疫苗为主。近年来,随着基因工程技术的发展,亚单位疫苗、病毒样颗粒疫苗、重组活载体疫苗、转基因植物疫苗和核酸疫苗等的研究也都取得了突破性进展。由于PEDV变异频繁,不断给疫苗研发带来新的挑战,高效的疫苗研发平台及基因工程疫苗对未来PED防控至关重要。本文对PEDV的病原学特征和最新的疫苗研究进展进行了系统综述,并展望未来的疫苗发展方向,以期为有效防控PED提供参考依据。The porcine epidemic diarrhea(PED)is an infectious intestinal disease caused by porcine epidemic diarrhea virus(PEDV),which results in an outbreak of diarrhea in pigs and high mortality in newborn piglet.In 2010,a highly pathogenic mutant strain of PEDV emerged and spread globally,which has presently been one of the main pathogens of porcine diarrhea and caused large losses for the global swine industry.Vaccination is the primary measure for preventing and controlling PED.Currently,available commercial PED vaccines mainly consist of traditional inactivated and attenuated vaccines.With the development of genetic engineering technologies in recent years,significant advancements have been made in the study of subunit vaccines,virus-like particle vaccines,recombinant vector vaccines,transgenic plant vaccines,and nucleic acid vaccines.The frequent variations of PEDV continues to bring new challenges to the vaccine development.Therefore,efficient vaccine development platforms and engineering vaccines are crucial for future prevention and control of PED.This article provides a systematic review of the pathogenic characteristics of PEDV and the latest advancements in vaccine research,as well as prospects for future vaccine development,aiming to provide a reference for effective prevention and control of PED.

关 键 词：猪流行性腹泻 猪流行性腹泻病毒 灭活疫苗 弱毒疫苗 基因工程疫苗 核酸疫苗 

分 类 号：S8285.3[农业科学—畜牧学] S852.659.6[农业科学—畜牧兽医]