细胞焦亡及其在角膜炎疾病中的作用机制研究进展  

Progress of Pyroptosis and Its Mechanism of Action in the Keratitis Disease

作　　者：王志浩 郭龙[1,2] 王培莉 李建基 王亨[1,2] WANG Zhihao;GUO Long;WANG Peili;LI Jianji;WANG Heng(Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Joint International Research Laboratory of Agriculture and Agri-product Safety of the Ministry of Education,Joint International Research Laboratory of Important Animal Infectious Diseases and Zoonoses of Jiangsu Higher Education Institutions,Yangzhou 225009,China;The Third School of Clinical Medicine,Nanjing University of Chinese Medicine,Shi Zi Street No.100,Hongshan Road,Nanjing 210028,China)

机构地区：[1]扬州大学兽医学院,江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州225009 [2]江苏高校动物重要疫病和重要人兽共患病防控技术国际合作联合实验室,农业与农产品安全教育部国际联合研究实验室,扬州225009 [3]南京中医药大学第三临床医学院,南京210028

出　　处：《畜牧兽医学报》2025年第3期1089-1099,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点研发计划资助项目(2023YFD1801100);江苏省研究生培养创新工程资助项目(KYCX21_3273);扬州大学卓越本科课程建设工程项目资助(2022ZYKCC-33);扬州大学“青蓝工程”资助;江苏省333高层次人才培养工程资助项目;江苏高校优势学科建设工程资助项目;江苏高校品牌专业建设工程资助项目;江苏省高等学校基础科学(自然科学)研究面上项目(22KJB230006)。

摘　　要：角膜炎是由于角膜防御能力降低,外界病原体或自身疾病等因素侵袭角膜组织所引发的炎症反应。细胞焦亡是一种与炎症相关的程序性细胞死亡方式,其在细胞膜上形成的孔道,可允许多种炎性介质的外排,介导炎症反应。有研究显示,角膜炎与焦亡的发生相关,抑制焦亡的发生可改善角膜炎的症状,是临床治疗的新方向。本文从细胞焦亡的定义及形态学变化、焦亡的发生机制、焦亡在角膜炎中的作用、常见焦亡抑制剂在眼科疾病中应用四个方面进行回顾和总结,以期推动焦亡在角膜炎疾病防控中的研究进程。Keratitis is an inflammation of the cornea caused by external pathogens or diseases,due to a reduction in the corneal defense ability.Pyroptosis is a programmed cell death related to inflammation.The pores formed on the cell membrane can allow the efflux of various inflammatory substances and mediate the inflammatory response.Studies have shown that keratitis is related to the occurrence of pyroptosis.Inhibiting the occurrence of pyroptosis can improve the clinical symptoms of the disease,which is a new direction for clinical treatment.This article reviews and summarizes the definition and morphological changes of pyroptosis,the mechanism of pyroptosis,the role of pyroptosis in keratitis,and the application of common pyroptosis inhibitors in ophthalmic diseases,to promote the research process of pyroptosis in keratitis.

关 键 词：细胞焦亡 角膜炎 防控 炎症反应 

分 类 号：S845[农业科学—畜牧兽医]