围产期B族链球菌感染研究进展  

Research progress on perinatal group B Streptococcus Infection

作　　者：张婷[1] 陈静 王晶 董蕊锐 王高莹 高建一 ZHANG Ting;CHEN Jing;WANG Jing;DONG Ruirui;WANG Gaoying;GAO Jianyi(Wuxi Maternity and Child Health Care Hospital,Wuxi,Jiangsu 214002,China;Wuxi School of Medicine,Jiangnan University,Wuxi,Jiangsu 214122,China)

机构地区：[1]无锡市妇幼保健院检验科,江苏无锡214002 [2]江南大学无锡医学院,江苏无锡214122

出　　处：《中国热带医学》2024年第12期1494-1500,共7页China Tropical Medicine

基　　金：国家自然科学基金项目(No.82171674);江苏省自然科学基金面上项目(No.BK20241759);江苏省卫生健康委医学科研面上项目(No.M2021023);江苏省卫生健康委“六个一工程”拔尖人才项目(No.LGY2020023);无锡市卫生健康委转化医学科研项目(No.ZH202109);无锡市“双百”中青年医疗卫生拔尖人才项目(No.BJ2020077);无锡市科技发展资金项目(No.Y20232003)

摘　　要：B族链球菌(Group B Streptococcus, GBS)广泛定植于人体胃肠道和泌尿生殖道。作为围产期的主要致病菌之一,GBS是危害孕产妇及新生儿健康的重要病原体,也是导致新生儿死亡的重要因素之一。GBS可侵袭性感染母体,如绒毛膜羊膜炎、产褥感染、胎膜早破等。在分娩过程中,GBS亦可通过上行或垂直传播致胎儿或新生儿感染,引发新生儿脑膜炎、败血症、肺炎等严重并发症,给新生儿生命健康带来严重威胁。GBS具有与黏附、免疫逃避、侵袭损伤相关的诸多毒力因子,可促进细菌的黏附和损伤,最终进展为侵袭性疾病。为降低GBS感染的风险,许多国家已经建立了产前GBS的普遍筛查和产时抗生素预防治疗策略,但目前仍有一定局限性。系统全面地探讨GBS感染的临床特征、毒力因子、实验室检测方法和疫苗现状等内容,为改善GBS感染的预防策略提供参考依据。Group B Streptococcus(GBS)is widely colonized in the human gastrointestinal and urogenital tracts.As one of the major pathogens during the perinatal period,GBS is an important pathogen that endangers the health of pregnant women and newborns and is also one of the important factors leading to neonatal mortality.GBS can cause invasive maternal infections such as chorioamnionitis,puerperal infections,and premature rupture of membranes.During delivery,GBS can also be transmitted to the fetus or newborn through ascending or vertical infections,causing serious complications such as neonatal meningitis,sepsis,and pneumonia,which pose serious threats to the life and health of newborns.GBS possesses numerous virulence factors related to adhesion,immune evasion,and invasive damage,which can promote bacterial adhesion and damage ability,ultimately leading to invasive diseases.To reduce the risk of GBS infection,many countries have established universal prenatal screening and prenatal antibiotic prophylaxis strategies,though there are still certain limitations at present.This article systematically and comprehensively explores the clinical characteristics,virulence factors,laboratory testing methods,and vaccine status of GBS infection,providing reference for improving prevention strategies for GBS infection.

关 键 词：B族链球菌 感染 毒力因子 检测方法 疫苗 

分 类 号：R378.12[医药卫生—病原生物学]