白细胞介素-18和白细胞介素-37b与嗜碱粒细胞在脓毒症中的作用研究进展  

Research advance on the role of interleukin-18,interleukin-37b and basophils in sepsis

作　　者：王君灵 董鑫 湛萌萌 秦秉玉 Wang Junling;Dong Xin;Zhan Mengmeng;Qin Bingyu(Department of Critical Care Medicine,Zhengzhou University People's Hospital(Henan Provincial People's Hospital),Zhengzhou 450003,Henan,China)

机构地区：[1]郑州大学人民医院(河南省人民医院)重症医学部,郑州450003

出　　处：《中华危重病急救医学》2025年第1期77-80,共4页Chinese Critical Care Medicine

基　　金：河南省科技发展计划项目(232102311022);河南省博士后科研项目(HN2022097);河南省自然科学基金(202300410458)。

摘　　要：近年来,白细胞介素-18(IL-18)和IL-37b因在炎症反应中发挥生物拮抗作用而成为研究热点。脓毒症是由感染诱导机体异常炎症反应导致的危及生命的器官功能障碍,脓毒性休克是其最严重的形式,并因致死率高而在临床研究中一直备受关注。嗜碱粒细胞是炎症反应中的经典效应细胞之一,参与了脓毒症病理过程的多个方面。IL-18是一种重要的促炎细胞因子,在炎症反应中发挥着关键作用;而IL-37b则以抗炎功能著称。IL-18和IL-37b均可通过白细胞介素-18受体α(IL-18Rα)反向调控嗜碱粒细胞的功能及脓毒症的炎症反应。因此,研究IL-18、IL-37b和嗜碱粒细胞在脓毒症发病中的作用及其机制具有重要的临床意义。本文通过总结IL-18、IL-37b和嗜碱粒细胞在脓毒症发病中的作用及其潜在机制相关文献,以期为以后开展IL-18、IL-37b及嗜碱粒细胞在脓毒症中的作用相关研究提供理论基础和新思路。Interleukin-18(IL-18)and IL-37b have recently become a research hotspot because of their biological antagonistic role in inflammatory response.Sepsis is an abnormal inflammatory response-mediated life-threatening organ dysfunction induced by infection.Septic shock is the most severe form of sepsis,and has attracted great attention in clinical research due to its high mortality.Basophils are one of the classical effector cells in the inflammatory response,which are involved in many aspects of the pathological process of sepsis.IL-18 is an important pro-inflammatory cytokine and plays a key role in the inflammatory response,while IL-37b is known for its anti-inflammatory function.Both IL-18 and IL-37b can regulate the function of basophils and the inflammatory response in sepsis reversely through interleukin-18 receptorα(IL-18Rα).Therefore,it is of great clinical significance to investigate the role and mechanism of IL-18,IL-37b and basophils in the pathogenesis of sepsis.Herein,the relevant literatures on the roles and potential mechanisms of IL-18,IL-37b and basophils in the pathogenesis of sepsis are summarized,aiming to provide theoretical basis and novel ideas for the future research on the potential roles of IL-18,IL-37b and basophils in sepsis.

关 键 词：脓毒症 嗜碱粒细胞 白细胞介素-18/白细胞介素-37b 

分 类 号：R459.7[医药卫生—急诊医学]