心力衰竭转化研究的新进展  

Recent advances in translational research on heart failure

作　　者：邹云增[1] 王琦 ZOU Yunzeng;WANG Qi(Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai,200232,China;Department of General Practice,Zhongshan Hospital,Fudan University)

机构地区：[1]复旦大学附属中山医院上海市心血管病研究所,上海200232 [2]复旦大学附属中山医院全科医学科

出　　处：《临床心血管病杂志》2025年第1期9-13,共5页Journal of Clinical Cardiology

摘　　要：几十年来,尽管心力衰竭(心衰)的治疗取得了相当大的进展,但心衰依然是全世界最主要的死亡原因之一。绝大多数能够诱发心衰的心血管疾病受到遗传和环境因素影响,基础及转化研究领域的最新研究进展,如遗传分析和单细胞分析,有助于揭示心衰的发病机制或病理生理机制,有望在心衰的诊断和预后分层方面发挥作用,为开发新的治疗手段提供新的思路和方法。本文主要阐述心衰转化研究方面的最新进展。Despite significant progress in the treatment of heart failure over the past few decades,heart failure remains one of the leading causes of death worldwide.Most cardiovascular diseases that predispose individuals to heart failure are caused by genetic and environmental factors.Recent advances in basic and translational research fields,such as genomic analysis and single-cell analysis,has shown great potential for unveiling the pathogenesis and/or pathophysiology,and can contribute to the diagnosis and prognostic stratification of heart failure,which provide new ideas and methods for the development of novel treatment methods.Here,we summarize the recent advances in translational research on heart failure.

关 键 词：心力衰竭 转化研究 遗传分析 单细胞分析 

分 类 号：R541.6[医药卫生—心血管疾病]