多巴胺系统通路相关基因多态性与吸烟行为的研究进展  

Research progress on gene polymorphisms in the dopaminesystem pathway and smoking behavior

作　　者：迟子美 揭秉章[1] 韩凌[1] CHI Zimei;JIE Bingzhang;HAN Ling(Department of Cardiology,Fuxing Hospital,Capital Medical University,Beijing,100038,China)

机构地区：[1]首都医科大学附属复兴医院心血管内科,北京100038

出　　处：《临床心血管病杂志》2025年第1期74-78,共5页Journal of Clinical Cardiology

基　　金：首都临床特色应用研究(No:Z181100001718069)。

摘　　要：烟草内的尼古丁增加大脑中多巴胺(dopamine,DA)等兴奋类神经递质的释放,同时,DA系统通路中的部分基因作为重要的吸烟相关基因,可能对尼古丁成瘾有影响。研究显示,尼古丁可能通过促进乙酰胆碱与其受体结合以及改变DA合成及转运途经的受体与酶的基因多态性达到依赖成瘾结果。DA系统与吸烟行为存在一定的正相关关系,这一结论或许能为更好地聚焦重点人群以降低吸烟率及分析烟草依赖特点提供理论基础。Nicotine in tobacco enhances the release of excitatory neurotransmitters such as dopamine(DA)in the brain.Concurrently,some genes in the DA system pathway as important smoking-related genes,may have an impact on nicotine addiction.Researches have shown that nicotine may facilitate addiction by promoting acetylcholine binding to its receptor,while also altering gene polymorphisms associated with receptors and enzymes involved in DA synthesis and transport pathways.It can be concluded that there exists a certain positive correlation between the DA system and smoking behavior,this conclusion may provide a theoretical foundation for targeting critical populations to reduce smoking rates and to analyze the attributes of tobacco dependence.

关 键 词：多巴胺系统通路 基因多态性 尼古丁 吸烟行为 

分 类 号：R54[医药卫生—心血管疾病]