基于中西医临床病证特点的甲状腺肿动物模型分析  

Analysis of Animal Models of Goiter Based on the Clinical Disease-Syndrome Characteristics in Traditional Chinese and Western Medicine

作　　者：余喻先 王雪纯 宫欢欢 李秀敏 苗明三[1] YU Yuxian;WANG Xuechun;GONG Huanhuan;LI Xiumin;MIAO Mingsan(Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学中医药科学院,郑州450046

出　　处：《中药药理与临床》2025年第1期124-128,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局标准化项目(编号:GZY-FJS-2020-219);河南省重大公益专项(编号:201300310100);河南省中医药科学研究专项课题(编号:20-21ZYZD02)。

摘　　要：甲状腺肿是临床常见病,发病率逐渐增高,研究相关动物模型与治疗药物是未来研究甲状腺肿疾病的重点。本文基于甲状腺肿的临床病证特点,查阅文献及临床诊断标准,对现有的甲状腺肿动物模型优缺点及临床症状匹配度进行分析探讨。统计结果发现已有的甲状腺肿动物模型大多以西医病因为基础建立,模型单一,与该病的西医症状吻合度高,缺乏一套完整的能够全面模拟甲状腺肿中医病证特点的造模方法。因此,改进完善能够充分体现中医证候特点的甲状腺肿动物模型,规范该动物模型的评价标准,是研究甲状腺肿疾病的关键。Goiter is a common clinical disease,and the incidence is on the rise.The study of related animal models and therapeutic drugs is the focus of research on goiter in the future.Based on the clinical disease-syndrome characteristics of goiter and according to the literature and clinical diagnostic criteria,this paper analyzed and discussed the advantages and disadvantages of the existing animal models of goiter and the matching degree with clinical symptoms.According to the statistical results,the majority of the existing animal models of goiter are established based on the etiology in western medicine with single types,which are highly consistent with the symptoms of western medicine.There is a lack of an integrated set of modeling methods that can fully imitate the disease-syndrome characteristics of goiter in traditional Chinese medicine(TCM).Therefore,it is critical to improve the animal models for goiter which can fully reflect the syndrome characteristics of TCM and standardize the assessment criteria in the study of goiter.

关 键 词：甲状腺肿 动物模型 中西医病证结合 

分 类 号：R58[医药卫生—内分泌]