甲型流感患儿白细胞分类特点及中西医结合治疗疗效分析  

Classification characteristics of leukocytes in children with influenza A and analysis of the efficacy of integrated traditional Chinese and western medicine treatment

作　　者：罗京资 胡汉斌 湛昌文 LUO Jingzi;HU Hanbin;ZHAN Changwen(Department of Clinical Laboratory,Guangzhou Hospital of Integrated Traditional and Western Medicine,Guangzhou,Guangdong 510800,China)

机构地区：[1]广州市中西医结合医院检验科,广东广州510800

出　　处：《热带医学杂志》2025年第1期72-75,共4页Journal of Tropical Medicine

基　　金：广东省基础与应用基础研究基金(省企联合基金)(2023A1515220084)。

摘　　要：目的探讨甲型流感(简称甲流)儿童病例外周血白细胞分类特点,分析奥司他韦联合中药治疗甲型流感的疗效。方法选取广州市中西医结合医院2023年4-12月收治的90例3~14岁甲流患儿为甲流组,另选取同期3~14岁健康体检的90名儿童作为对照组。比较两组儿童外周血白细胞分类差异。同时将甲流患儿随机分为治疗组(n=45)和联合组(n=45),治疗组采取奥司他韦治疗,联合组采取奥司他韦联合中药辩证治疗,比较治疗组和联合组的临床症状指标评分差异。结果甲流组患儿中性粒细胞百分比(65.34±12.18)%、单核细胞百分比(10.80±3.22)%均高于对照组[(58.84±18.22)%、(10.25±3.64)%];淋巴细胞百分比(22.68±10.63)%低于对照组(25.38±15.66)%,差异均有统计学意义(t=6.091、3.112、7.135,P均<0.05)。甲流组白细胞水平为(7.02±2.38)×10^(9)/L,对照组为(6.04±3.64)×10^(9)/L,差异无统计学意义(t=0.255,P=0.613)。治疗后,联合组发热(1.14±0.37)分、咽痛(1.02±0.34)分、乏力(1.07±0.29)及咳嗽(1.16±0.32)分等临床指标评分均低于治疗组(1.54±0.46)、(1.48±0.31)、(1.57±0.39)、(1.61±0.33)分,差异均有统计学意义(t=4.633、4.724、6.112、5.324,P均<0.05)。结论中药联合奥司他韦治疗流感可促使症状有效缓解,增强临床疗效,值得进一步推广。Objective To investigate the characteristics of peripheral blood leukocyte classification in children with influenza A and analyze the efficacy of oseltamivir combined with Chinese medicine in the treatment of influenza A.Methods A total of 90 children aged 3-14 years old who were admitted to the Guangzhou Hospital of Integrated Traditional and Western Medicine from April 2023 to December 2023 were selected as the study object as the A/H1N1 group,and 90 healthy children aged 3-14 years old during the same period were selected as the control group.The differences in the classification of peripheral blood leukocytes between the two groups were compared.At the same time,the children were randomly divided into the treatment group and the combination group.The treatment group was treated with oseltamivir,and the combination group was treated with oseltamivir combined with traditional Chinese medicine.The differences in clinical symptom index scores between the treatment group and the combination group were compared.Results The percentage of neutrophils(65.34±12.18)%and monocytes(10.80±3.22)%in children with influenza A were higher than those in the control group(58.84±18.22)%,(10.25±3.64)%;the percentage of lymphocytes(22.68±10.63)%was lower than that of the control group(25.38±15.66)%,and the difference was statistically significant(t=6.091,3.112,7.135;all P<0.05).The white blood cell level in the A/H1N1 group was(7.02±2.38)×10^(9)/L,while that of the control group was(6.04±3.64)×10^(9)/L,with no statistically significant difference(t=0.255,P=0.613).After treatment,the clinical indicators scores of fever(1.14±0.37),sore throat(1.02±0.34),fatigue(1.07±0.29),and cough(1.16±0.32)in the combination group were lower than those in the treatment group(1.54±0.46),(1.48±0.31),(1.57±0.39),(1.61±0.33),and the difference was statistically significant(t=4.633,4.724,6.112,5.324;all P<0.05).Conclusion The combination of traditional Chinese medicine and oseltamivir could effectively alleviate symptoms and enhance c

关 键 词：甲型流感 白细胞分类 奥司他韦 中药 

分 类 号：R511.7[医药卫生—内科学]