IP3R钙离子通道与呼吸系统相关疾病的研究进展  

Research advances in IP3R calcium ion channels and respiratory system-related diseases

作　　者：谢欣芸 黄燕 党傲 花荣 张家春 杨朝 XIE Xinyun;HUANG Yan;DANG Ao;HUA Rong;ZHANG Jiachun;YANG Zhao(Department of Respiratory and Oncology,Chengdu Sixth People’s Hospital,Chengdu,Sichuan 610051,China;Department of Respiratory Medicine,Suzhou Science and Technology City Hospital Affiliated with Nanjing Medical University,Suzhou,Jiangsu 215153,China)

机构地区：[1]成都市第六人民医院呼吸肿瘤科,成都610051 [2]南京医科大学附属苏州科技城医院呼吸科,江苏苏州215153

出　　处：《重庆医学》2025年第3期770-774,共5页Chongqing Medical Journal

基　　金：国家自然科学基金项目(81560014);江苏省自然科学基金项目(BK20201183);江苏省“双创人才”项目(JSSCRC2021568)。

摘　　要：慢性阻塞性肺疾病、哮喘、肺动脉高压等多种呼吸系统疾病的发病机制至今仍不完全清楚,但越来越多的研究发现,钙离子通道在上述呼吸系统疾病的发病机制中具有重要作用。钙离子作为重要的第二信使,能够参与人体内众多的生理和病理过程。研究表明1,4,5-三磷酸肌醇受体(IP3R)通道主要参与钙离子浓度和分布的平衡,当平衡被打破,便可导致慢性阻塞性肺疾病、哮喘等呼吸系统疾病发生,而IP3R通道在呼吸系统疾病中的作用仍需进一步探索。The pathogenesis of respiratory diseases such as chronic obstructive pulmonary disease(COPD),asthma,and pulmonary hypertension remains incompletely understood.However,accumulating evidence suggests that calcium ion channels play a critical role in these disorders.As a key second messenger,calcium ions regulates diverse physiological and pathological processes.Studies indicate that calcium ion homeostasis,including their concentration and distribution and spatial distribution is mediated primarily through inositol 1,4,5-trisphosphate receptor(IP3R)channel.Disruption of this homeostasis may contribute to the development of COPD,asthma,and other respiratory diseases.Nevertheless,the role of IP3R channels in respiratory diseases require further investigation.

关 键 词：钙离子 1 4 5-三磷酸肌醇受体 呼吸系统疾病 

分 类 号：R56[医药卫生—呼吸系统]