AECOPD病情严重程度与血清IL-8、IL-26水平的相关性研究  

Correlation study between severity of AECOPD and serum IL-8,IL-26 levels

作　　者：陈丁丁 刘冬[1] 张文文 张欣欣 林智峰[1] CHEN Dingding;LIU Dong;ZHANG Wenwen;ZHANG Xinxin;LIN Zhifeng(the First Affiliated Hospital of Shihezi University,Shihezi 832008,China)

机构地区：[1]石河子大学第一附属医院,新疆石河子832008

出　　处：《临床医学研究与实践》2025年第9期37-41,共5页Clinical Research and Practice

基　　金：石河子大学2023年度兵团指导性科技计划项目(No.2023ZD019)。

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)病情严重程度与血清白细胞介素-8(IL-8)、白细胞介素-26(IL-26)水平的相关性。方法选取2022年10月至2023年5月在石河子大学第一附属医院明确诊断为AECOPD的116例患者作为AECOPD组,根据BODE评分将其分为BODE 1级组(30例)、BODE 2级组(31例)、BODE 3级组(30例)、BODE 4级组(25例),选取同期门诊随诊的30例慢性阻塞性肺疾病(COPD)稳定期患者作为稳定期组,体检中心健康体检无异常的30名体检者作为对照组。检测并比较各组血清IL-8、IL-26水平;分析血清IL-8、IL-26水平与AECOPD的相关性及其对AECOPD的预测价值。结果AECOPD组的IL-8、IL-26水平高于稳定期组、对照组,差异具有统计学意义(P<0.05);稳定期组的IL-26水平高于对照组,差异具有统计学意义(P<0.05)。BODE 3级组的IL-8水平高于对照组、稳定期组、BODE 1级组、BODE 2级组,差异具有统计学意义(P<0.05);BODE 4级组的IL-8水平高于对照组、稳定期组、BODE 1级组、BODE 2级组、BODE 3级组,差异具有统计学意义(P<0.05);BODE 3级组的IL-26水平高于对照组、稳定期组、BODE 1级组,差异具有统计学意义(P<0.05);BODE 4级组的IL-26水平显著高于对照组、稳定期组、BODE 1级组、BODE 2级组,差异具有统计学意义(P<0.05)。二元Logistic回归分析结果显示,IL-8、IL-26是AECOPD的危险因素(P<0.05)。IL-8、IL-26预测AECOPD的受试者工作特征(ROC)曲线下面积分别为0.693、0.763。结论血清IL-8、IL-26均为AECOPD的危险因素,其水平可作为判定COPD严重程度的方法之一。Objective To explore the correlation between severity of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and serum interleukin-8(IL-8),interleukin-26(IL-26)levels.Methods A total of 116 patients with AECOPD diagnosed in the First Affiliated Hospital of Shihezi University from October 2022 to May 2023 were selected as AECOPD group.According to the BODE score,the patients were divided into BODE grade 1 group(30 cases),BODE grade 2 group(31 cases),BODE grade 3 group(30 cases)and BODE grade 4 group(25 cases).Thirty patients with stable chronic obstructive pulmonary disease(COPD)who were followed up in the outpatient clinic during the same period were selected as stable group,and 30 healthy subjects in the physical examination center were selected as control group.The levels of serum IL-8 and IL-26 in each group were detected and compared;the correlation between serum levels of IL-8 and IL-26 and AECOPD and their predictive value for AECOPD were analyzed.Results The levels of IL-8 and IL-26 in the AECOPD group were higher than those in the stable group and the control group,and the differences were statistically significant(P<0.05);the level of IL-26 in the stable group was higher than that in the control group,and the difference was statistically significant(P<0.05).The level of IL-8 in the BODE grade 3 group was higher than that in the control group,the stable group,the BODE grade 1 group and the BODE grade 2 group,and the difference was statistically significant(P<0.05);the level of IL-8 in the BODE grade 4 group was higher than that in the control group,the stable group,the BODE grade 1 group,the BODE grade 2 group and the BODE grade 3 group,and the difference was statistically significant(P<0.05);the level of IL-26 in the BODE grade 3 group was higher than that in the control group,the stable group and the BODE grade 1 group,and the difference was statistically significant(P<0.05);the level of IL-26 in the BODE grade 4 group was significantly higher than that in the control group,the stable gro

关 键 词：慢性阻塞性肺疾病急性加重期 白细胞介素-8 白细胞介素-26 BODE评分 

分 类 号：R563[医药卫生—呼吸系统]