丹参多酚酸盐联合沙库巴曲缬沙坦钠治疗慢性心力衰竭的效果及对心室重构、血管内皮功能的影响  

Effect of salvianolate combined with sacubitril valsartan sodium in the treatment of chronic heart failure and its influences on ventricular remodeling and vascular endothelial function

作　　者：蔺赛 李丽媛 LIN Sai;LI Liyuan(No.2 Internal Medicine Department,Shaanxi Aerospace Hospital,Xi'an 710025,China)

机构地区：[1]陕西航天医院内二科,陕西西安710025

出　　处：《临床医学研究与实践》2025年第9期54-57,共4页Clinical Research and Practice

摘　　要：目的探讨丹参多酚酸盐联合沙库巴曲缬沙坦钠治疗慢性心力衰竭的效果。方法选取2020年6月至2023年8月收治的128例慢性心力衰竭患者,将其随机分为对照组和观察组,每组64例。对照组给予沙库巴曲缬沙坦钠治疗,观察组给予丹参多酚酸盐联合沙库巴曲缬沙坦钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的室间隔厚度(IVST)、左心室后壁厚度(LVPWT)小于对照组,左心室质量指数(LVMI)大于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的内皮素(ET)水平低于对照组,降钙素基因相关肽(CGRP)、一氧化氮(NO)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的透明质酸(HA)、层粘连蛋白(LN)及Ⅲ型前胶原(PCⅢ)水平低于对照组,差异具有统计学意义(P<0.05)。结论丹参多酚酸盐联合沙库巴曲缬沙坦钠治疗慢性心力衰竭患者的效果显著,能够改善心室重构、血管内皮功能,并减轻心肌纤维化程度。Objective To investigate the effect of salvianolate combined with sacubitril valsartan sodium in the treatment of chronic heart failure.Methods A total of 128 patients with chronic heart failure admitted from June 2020 to August 2023 were selected and randomly divided into control group and observation group,with 64 cases in each group.The control group was treated with sacubitril valsartan sodium,and the observation group was treated with salvianolate combined with sacubitril valsartan sodium.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the interventricular septal thickness(IVST)and left ventricular posterior wall thickness(LVPWT)in the observation group were smaller than those in the control group,the left ventricular mass index(LVMI)was larger than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of endothelin(ET)in the observation group was lower than that in the control group,the levels of calcitonin gene-related peptide(CGRP)and nitric oxide(NO)were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of hyaluronic acid(HA),laminin(LN)and procollagenⅢ(PCⅢ)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Salvianolate combined with sacubitril valsartan sodium has a significant effect in the treatment of patients with chronic heart failure,it can improve ventricular remodeling,vascular endothelial function,and reduce the degree of myocardial fibrosis.

关 键 词：丹参多酚酸盐 沙库巴曲缬沙坦钠 慢性心力衰竭 心室重构 血管内皮功能 

分 类 号：R541.6[医药卫生—心血管疾病]