舍曲林对抑郁合并心力衰竭疗效的Meta分析  

Meta-analysis of the efficacy of sertraline in the treatment of depression complicated with heart failure

作　　者：李向庚 高媛[2] 杨浩[2] 孙淑艳[2] LI Xianggeng;GAO Yuan;YANG Hao;SUN Shuyan(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040;No.3 Cardiology Department,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia Universityof Science and Technology,Baotou 014000,China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院心内三科,内蒙古包头014000

出　　处：《临床医学研究与实践》2025年第9期98-101,共4页Clinical Research and Practice

摘　　要：目的系统评价舍曲林对抑郁合并心力衰竭患者的治疗效果,为临床治疗抑郁合并心力衰竭提供参考依据。方法在知网、维普、CBM、PubMed、Embase、Cochrane Library、Web of Science数据库中检索舍曲林治疗抑郁合并心力衰竭的随机对照试验(RCT)文献,检索时间均从建库至2022年12月。由2名研究人员依据纳入及排除标准进行文献筛选,提取汉密尔顿抑郁量表(HAMD)、左心室射血分数(LVEF)为结局指标。采用Cochrane偏倚风险评估工具对纳入文献进行质量评价,采用RevMan5.3软件进行Meta分析。结果共纳入4篇RCT文献,450例患者,其中试验组227例,对照组223例。Meta分析结果显示,试验组与对照组的HMAD评分比较,差异无统计学意义[均数差(MD)=-3.74,95%CI=-7.83~0.34,Z=1.80,P>0.05];试验组的LVEF显著高于对照组,差异具有统计学意义(MD=4.19,95%CI=3.01~5.36,Z=6.96,P<0.05)。结论舍曲林能够改善左心室收缩功能,可在某种程度上用于治疗抑郁合并心力衰竭,但对其他心脏指标和心功能的影响尚待进一步探究。Objective To systematically evaluate the therapeutic effect of sertraline on patients with depression complicated with heart failure,and to provide reference for clinical treatment of depression complicated with heart failure.Methods The databases of CNKI,VIP,CBM,PubMed,Embase,Cochrane Library and Web of Science were searched for randomized controlled trial(RCT)of sertraline in the treatment of depression complicated with heart failure,the retrieval time was from the establishment of the database to December 2022.Two researchers screened the literature according to the inclusion and exclusion criteria,and extracted the Hamilton Depression Scale(HAMD)and left ventricular ejection fraction(LVEF)as outcome indexes.The Cochrane bias risk assessment tool was used to evaluate the quality of the included literature,and RevMan5.3 software was used for Meta-analysis.Results A total of 4 RCT literatures with 450 patients were included,including 227 case in the experimental group and 223 case in the control group.The results of Meta-analysis showed that there was no significant difference in HMAD score between the experimental group and the control group[mean difference(MD)=-3.74,95%CI=-7.83~0.34,Z=1.80,P>0.05];the LVEF of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(MD=4.19,95%CI=3.01~5.36,Z=6.96,P<0.05).Conclusion Sertraline can improve left ventricular systolic function and can be used to treat depression complicated withheart failure to some extent,but its effect on other cardiac indicators and cardiac function remains to be further explored.

关 键 词：舍曲林 抑郁 心力衰竭 META分析 

分 类 号：R541.7[医药卫生—心血管疾病]