基于隐结构模型结合关联规则分析勃起功能障碍的方药规律  

Analysis of prescription laws for erectile dysfunction based on latent structure model and association rules

作　　者：马健 马紫阳 邓航 曾虹森 余茂彬 李泽 张培海[1] Ma Jian;Ma Ziyang;Deng Hang;Zeng Hongsen;Yu Maobin;Li Ze;Zhang Peihai(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China)

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]成都中医药大学,四川成都610075

出　　处：《中国男科学杂志》2025年第1期56-66,共11页Chinese Journal of Andrology

基　　金：国家自然科学基金(82474319,82405412)。

摘　　要：目的基于隐结构模型和关联规则分析中医药治疗勃起功能障碍(Erectile dysfunction,ED)的方药规律,为临床治疗ED提供理论参考。方法系统检索维普、万方、中国知网等数据库建库至2024年5月30日方药治疗ED的相关文献,构建数据库。利用Lantern 5.0和Rstudio软件对使用频率>4.00%的中药进行隐结构模型及关联规则分析,总结ED治疗的方药规律。结果研究共纳入174首中医处方,涉及191味中药,累计使用频次2032次。结果显示,高频使用的中药包括淫羊藿、柴胡等,主要功效为补虚药、活血化瘀药,中药性味以温、甘、辛为主,大多归属肝、肾、脾三经。隐结构分析共获得10个隐变量、20个隐类、7个综合聚类模型、12个核心方剂,证型以肾虚血瘀证、肝郁气滞证为主,关联规则分析获得35条强关联规则。结论ED为本虚标实之证,核心病机为“肾虚”“肝郁”“血瘀”,与肾、肝、脾关系密切,治法以温肾助阳为主,随证结合疏肝行气,活血化瘀治法。Objective To analyze the prescription laws of Chinese medicine for erectile dysfunction(ED)based on the latent structure model and association rules,and provide theoretical reference for clinical treatment of ED.Methods Relevant literatures on Chinese medicine for ED were systematically searched from the databases of VIP,Wanfang,and CNKI from its inception to 30 May 2024,and they were constructed into a database.Lantern 5.0 and Rstudio were used to analyze the latent structure model and association rules of traditional Chinese medicine with frequency of use>4.00%,and the prescription rules of ED were summarized.Results A total of 174 traditional Chinese medicine prescriptions involving 191 Chinese herbs were obtained in the study,with a cumulative frequency of use reaching 2032 times.Results revealed that frequently used traditional Chinese medicines(TCMs)in clinical practice included Epimedium,Bupleurum,and their major function was tonics,blood-activating and stasis-removing.The nature and flavor of these TCMs were predominantly warm,sweet,and pungent,mainly associated with the liver,kidney,and spleen meridians.Latent structure analysis yielded 10 latent variables,20 latent classes,and 7 comprehensive clustering models,along with 12 core formulas.The main syndrome types for ED were kidney deficiency with blood stasis,liver qi stagnation.The association rule analysis showed 35 strong association rules.Conclusion ED is considered a syndrome of deficiency with excess characteristics,and its core pathogenesis involves“kidney deficiency”“liver depression”,and“blood stasis”closely related to the kidneys,liver,and spleen.The treatment focuses on warming the kidney to reinforce yang,regulating the liver and promoting qi circulation based on the syndrome,as well as promoting blood circulation and removing blood stasis.

关 键 词：勃起功能障碍 隐结构模型 关联规则分析 

分 类 号：R698.1[医药卫生—泌尿科学] R289.69[医药卫生—外科学]