肾素-血管紧张素系统组分影响勃起功能障碍转归探析  

The influence of renin-angiotensin system components on the progression of erectile dysfunction

作　　者：马永杰 邹和德 曹芮 陈文康 张鹤坤 赵家有[1] Ma Yongjie;Zou Hede;Cao Rui;Chen Wenkang;Zhang Hekun;Zhao Jiayou(Graduate School,China Academy of Chinese Medical Sciences,Beijing 100700,China;Graduate School,Hebei University of Chinese Medicine,Shijiazhuang 050091,Hebei,China)

机构地区：[1]中国中医科学院研究生院,北京100700 [2]河北中医药大学研究生院,河北石家庄050091

出　　处：《中国男科学杂志》2025年第1期138-142,共5页Chinese Journal of Andrology

基　　金：中国中医科学院科技创新工程(CI2023C018YL);国家自然科学基金面上项目(82274337);首都卫生发展科研专项(首发2022-2-4271);中华中医药学会青年求实项目(2022-QNQSDEP-20)。

摘　　要：肾素-血管紧张素系统(Renin-angiotensin system,RAS)组分在心血管生理、病理中发挥重要作用,同时也在阴茎组织中高表达,影响生殖健康。RAS组分与血管性ED发病机制密切相关,ACE和AngⅡ表达水平升高可能导致ACE-AngⅡ-AT1R轴过度激活,对勃起功能产生负面影响;而ACE2和Ang(1-7)表达增加则可提高ACE2-Ang(1-7)-Mas保护轴活性,有效改善勃起功能。本文通过梳理RAS组分与血管性ED之间的相关研究,探讨RAS组分作为其预测指标和治疗新靶点的可能性,旨在为延缓ED发生发展、改善患者预后、提高其生活质量提供新策略。The components of renin-angiotensin system(RAS)not only play the important role in cardiovascular physiology and pathology,but also affects reproductive health due to highly expressed in penile tissues.RAS components are closely related to the pathogenesis of vascular erectile dysfunction(ED),and high expressions of ACE and AngⅡmay cause excessive activation of the ACE-AngⅡ-AT1R axis,which exerts a negative impact on erectile function,while increased expressions of ACE2 and Ang(1-7)may improve the activition of the ACE2-Ang(1-7)-Mas protective axis,which effectively strengthen erectile function.By reviewing the relevant studies between RAS components and vascular ED,this paper explores the possibility of RAS components as predictive indicators and new treatment targets for vascular ED,aims to provide new strategies to delay the development of ED,improve the prognosis of patients,and enhance their quality of life.

关 键 词：勃起功能障碍 肾素-血管紧张素系统 血管紧张素转换酶2 血管紧张素类 

分 类 号：R698.1[医药卫生—泌尿科学]