基于磁共振的肠易激综合征脑-脊-肠轴异常及针刺治疗机制探索  

Exploration of brain-spinal cord-gut axis abnormalities and the mechanism of acupuncture therapy in irritable bowel syndrome based on magnetic resonance imaging

作　　者：王晨曦 孔亚卓 刘继欣 Chenxi Wang;Yazhuo Kong;Jixin Liu(School of Life Science and Technology,Xidian University,Xi’an 710126,China;CAS Key Laboratory of Behavioral Science,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;Department of Psychology,Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]西安电子科技大学生命科学技术学院,西安710126 [2]中国科学院行为科学重点实验室(中国科学院心理研究所),北京100101 [3]中国科学院大学心理学系,北京100049

出　　处：《科学通报》2025年第8期959-967,共9页Chinese Science Bulletin

基　　金：国家重点研发计划(2022YFC3500603)资助。

摘　　要：肠易激综合征是由脑-肠交互紊乱引发的功能性胃肠疾病,以腹痛、腹胀、排便习惯改变为主要症状,影响全球5%~10%的人口.当前治疗主要集中于缓解患者腹痛和改善其排便习惯,但药物疗效有限且可能引发不良反应.针刺作为补充与替代疗法,在治疗肠易激综合征方面展现出潜力.尽管临床试验证实了针刺的治疗效果,但由于其生物学机制仍不明确,因此在全球医学界存在争议.脊髓在脑-肠交互中扮演着重要角色,磁共振成像技术的发展为深入探索基于脑-脊-肠轴的肠易激综合征发病机制和针刺起效机制提供了新的视角.本文综述了基于磁共振的肠易激综合征脑-脊-肠轴互动异常以及针刺治疗的相关研究.尽管目前在该病的发病机制和针刺治疗方面有所突破,但仍存在诸多不足.现有针对脊髓的影像研究仍显匮乏,这限制了我们对该病发病机制和针刺治疗机制的全面理解.未来应加强对脊髓影像的研究,深入剖析脑-脊-肠轴通路的作用机制,以期为揭示该病的发病机理及针刺治疗的起效机制提供科学依据.此外,现有的针刺对肠易激综合征影响的研究多偏重于现象描述与数据对比,缺乏与神经科学疼痛理论的结合.未来应注重与疼痛理论相融合,深入探讨针刺对疼痛传导与处理关键通路的影响,以期阐明针刺镇痛的复杂机制,进一步推动针刺治疗的应用.Irritable bowel syndrome(IBS)is a functional gastrointestinal disorder triggered by the disorder of brain-gut interaction and characterized by abdominal pain,bloating,and altered bowel habits.It is estimated to affect between 5%and 10%of the global population.Although IBS does not have an excessive mortality rate,the disease significantly affects the quality of life and can lead to significant disability.Current treatments mainly focus on relieving abdominal pain and improving bowel habits.However,the effect of drug therapy on the overall symptoms of patients is limited,and the majority of therapeutic drugs are associated with the risk of adverse reactions.Consequently,many patients turn to complementary and alternative therapies to achieve more favorable treatment outcomes.Acupuncture,as a complementary and alternative therapy,has shown potential in the treatment of IBS.Although clinical trials have confirmed the therapeutic effect of acupuncture,its mechanism of action remains unclear,leading to controversy in the global medical community.Researchers,leveraging magnetic resonance imaging(MRI)technology,strive to delve deeply into the biological mechanisms underlying the alleviation of irritable bowel syndrome symptoms through acupuncture therapy,aiming to provide solid support for the scientific basis and efficacy of this treatment method.However,current imaging research primarily focuses on changes in brain structure and function,relatively neglecting the close connection between spinal structure and function and IBS.The spinal cord plays a crucial role in brain-gut interaction,and the development of MRI technology provides a new perspective for exploring the pathogenesis of IBS and the mechanism of acupuncture based on the brain-spinal cord-gut axis.This paper reviews MRI-based studies on abnormalities in brain-spinal cord-gut axis interaction in IBS and acupuncture treatment.Although there have been significant advancements in understanding the causes and using acupuncture to treat IBS,there are still severa

关 键 词：肠易激综合征 针刺 磁共振 脑-脊-肠轴 

分 类 号：R24[医药卫生—中医临床基础]