清热类中药提取物对热应激奶牛生产性能的影响——基于Meta的分析  

Effects of Heat-Clearing Chinese Herbal Extracts on the Production Performance of Heat-Stressed Dairy Cows: A Meta-Analysis

作　　者：刘正清 倪鹏程 杨汉文 尹诗 王世康 张强 李道全 杨志强 LIU Zhengqing;NI Pengcheng;YANG Hanwen;YIN Shi;WANG Shikang;ZHANG Qiang;LI Daoquan;YANG Zhiqiang(Bright Farming Co.,Ltd./Key Laboratory of Dairy Cattles Genetic Improvement in Southern China of Ministry of Agriculture and Rural Affairs,Shanghai200436,China)

机构地区：[1]光明牧业有限公司/农业农村部南方奶牛遗传改良重点实验室,上海200436

出　　处：《畜牧与饲料科学》2025年第1期83-95,共13页Animal Husbandry and Feed Science

基　　金：国家奶牛产业技术体系(CARS-36)。

摘　　要：[目的]系统评价清热类中药提取物对热应激奶牛生产性能的影响,为缓解奶牛热应激提供指导和参考。[方法]从PubMed、中国知网(CNKI)、维普(CQVIP)、万方(WanFang)4个数据库检索已发表关于清热类中药提取物对热应激奶牛影响的文献,检索时间从各数据库建库至2024年8月。采用系统回顾法对文献进行Meta分析,使用Review Manager 5.4软件和SPSSAU网站对热应激奶牛的生产性能指标,包括产奶量、乳脂率、乳蛋白率、乳糖率和体细胞数(SCC)进行数据分析,而后再进行敏感性分析、亚组分析以及发表偏倚分析。[结果]通过严格的纳入和排除标准,筛选出了10篇具有随机对照试验(randomized controlled trials,RCTs)条件的研究文献,共涉及423头奶牛。清热类中药提取物的添加显著提升了热应激奶牛的产奶量(SMD=0.87,95%CI:0.63~1.11,P<0.00001)和乳脂率(SMD=0.43,95%CI:0.02~0.84,P=0.04),同时显著降低了牛奶中的体细胞数(SMD=-1.31,95%CI:-1.68~-0.95,P<0.0001),对乳蛋白率及乳糖率没有显著影响(P>0.05,P=0.67,0.49)。敏感性分析确认了Meta分析结果的稳定性和可信度,且未发现明显的发表偏倚。[结论]清热类中药提取物可以有效提升热应激奶牛的生产性能。[Objective]To systematically evaluate the effects of heat-clearing Chinese herbal extracts on the production performance of heat-stressed dairy cows,providing guidance and references for alleviating heat stress in dairy cows.[Methods]Published literature on the effects of heat-clearing Chinese herbal extracts on heat-stressed dairy cows was retrieved from four databases:PubMed,CNKI,CQVIP,and WanFang,with the search period spanning from the establishment of each database to August 2024.A systematic review method was used to conduct a Meta-analysis of the literature.Review Manager 5.4 software and the SPSAU website were used to analyze the data of the production performance indicators of dairy cows under heat stress,including milk yield,milk fat percentage,milk protein percentage,lactose percentage,and somatic cell count(SCC).Then,sensitivity analysis,subgroup analysis,and publication bias analysis were carried out.[Results]Based on strict inclusion and exclusion criteria,10 research articles meeting the conditions of randomized controlled trials(RCTs)were selected,involving 423 dairy cows.The addition of heat-clearing Chinese herbal extracts significantly increased milk yield[SMD=0.87,95%CI:(0.63,1.11),P<0.00001]and milk fat percentage[SMD=0.43,95%CI:(0.02,0.84),P=0.04]in heat-stressed dairy cows.Additionally,it significantly reduced somatic cell count in milk[SMD=-1.31,95%CI:(-1.68,-0.95),P<0.0001].No significant effects were observed on milk protein percentage or lactose percentage(P>0.05,P=0.67,0.49).Sensitivity analysis confirmed the stability and reliability of the meta-analysis results,and no significant publication bias was detected.[Conclusion]Heat-clearing Chinese herbal extracts can effectively enhance the production performance of heat-stressed dairy cows.

关 键 词：Meta分析 中药提取物 奶牛 热应激 生产性能 

分 类 号：S823.914[农业科学—畜牧学] S816.7[农业科学—畜牧兽医] G252.8[文化科学—图书馆学]