维生素D在生育、妊娠方面的研究进展  

Research progress on vitamin D in fertility and pregnancy

作　　者：王雪妮 李建华 Wang Xueni;Li Jianhua(Department of Human Anatomy,School of Basic Medical Sciences,Medical School of Qinghai University,Xining 810016,China)

机构地区：[1]青海大学医学部基础医学部人体解剖学教研室,西宁810016

出　　处：《解剖学杂志》2025年第1期64-67,共4页Chinese Journal of Anatomy

摘　　要：人类维生素D缺乏的现象越来越常见,已成为全球备受关注的公共卫生问题之一,尤其在高海拔地区居住的人群及白种人中更为显著。维生素D是一种人体必需的脂溶性维生素,大部分来源于皮肤经紫外线照射后合成,少部分从饮食中获取。维生素D本身并不具有活性,在体内经过2次羟化后才生成具有生物活性的骨化三醇,作用于靶器官或组织,参与体内多种生物反应,主要是钙磷代谢调节、免疫应答、细胞分化及凋亡等过程。越来越多的研究表明维生素D在人类生育、妊娠及哺乳等过程中发挥重要作用,本综述回顾了近几年维生素D在生育、妊娠方面的主要研究进展。Vitamin D deficiency is becoming increasingly common and has emerged as a globally concerned public health issue,especially among people living in high-altitude areas and among Caucasians.Vitamin D is an essential fat-soluble vitamin for the human body,primarily obtained through two main sources.Most of the vitamin D is synthesized in the skin after ultraviolet irradiation,and the other part can be obtained from the diet.Vitamin D itself is not biologically active.After two hydroxylation processes in the body,it produces bioactive calcitriol(1,25(OH)2D3),which acts on target organs or tissues and participates in a variety of biological reactions in the body.The reactions include the regulation of calcium and phosphorus metabolism,immune response,cell differentiation,and apoptosis.In recent years,more and more scholars in China and beyond have found that vitamin D is closely related to human fertility,pregnancy,and lactation.This article reviews the recent advances in research on the role of vitamin D in fertility and pregnancy.

关 键 词：维生素D 维生素D缺乏 妊娠 妊娠期并发症 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学] R71[医药卫生—基础医学]