miRNA在糖尿病心肌病中的靶向调控机制研究进展  

Research progress on the targeted regulatory mechanism of miRNA in diabetic cardiomyopathy

作　　者：张倩 刘学霖 张月梅[1] 欧小鹏 陈永清 ZHANG Qian;LIU Xuelin;ZHANG Yuemei;OU Xiaopeng;CHEN Yongqing(Gansu University of Chinese Medicine,Lanzhou,730000,China;Department of Cardiology,Gansu Provincial Central Hospital)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中心医院心内科

出　　处：《临床心血管病杂志》2025年第2期150-155,共6页Journal of Clinical Cardiology

基　　金：甘肃省自然科学基金(No:23JRRA1377);兰州市科技计划项目(No:2022-5-84)。

摘　　要：糖尿病心肌病是在糖尿病存在的情况下出现的心肌收缩和(或)舒张功能障碍,严重危害人类健康。虽然对糖尿病心肌病的发病机制进行了广泛的研究,但其调控机制尚不明确。近年来的研究发现,miRNA特异性结合miRNA分子的3’-非翻译区的碱基序列,参与靶标的调控,在糖尿病心肌病的发生发展中发挥重要作用。本文就miRNA在糖尿病心肌病发病中的重要作用进行综述,以期为今后的研究提供参考。Diabetic cardiomyopathy(DCM)is a systolic or diastolic myocardial dysfunction in diabetes,which seriously endangers human health.It is still unclear although the pathogenesis of DCM has been extensively studied.Recent studies have found that miRNA specifically binds to the base sequence of the 3'-untranslated region of mRNA molecules,participates in the regulation of targets,and plays an important role in the occurrence and development of DCM.This article reviews the important role of miRNA in the pathogenesis of DCM,in order to provide a reference for future research.

关 键 词：糖尿病心肌病 MIRNA 3′-UTR 铁死亡 巨噬细胞极化 焦亡 表观遗传学 

分 类 号：R542.2[医药卫生—心血管疾病]