白癜风与代谢性疾病发病机制的相关性研究  

Research progress on relationship between vitiligo and metabolic disease

作　　者：石静艺 王红娟[1] 康晓静[1] SHI Jingyi;WANG Hongjuan;KANG Xiaojing(Department of Dermatology and Venereology,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatologic Diseases,Xinjiang Key Laboratory of Dermatology Research,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科,新疆皮肤病临床医学研究中心,新疆皮肤病研究重点实验室,乌鲁木齐830001

出　　处：《中国免疫学杂志》2025年第3期767-768,F0003,F0004,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(82173406);新疆维吾尔自治区“天山英才”培养计划(2022TSYCLJ0025)。

摘　　要：白癜风是一种获得性色素脱失性皮肤病,以表皮黑素细胞缺失形成的色素脱失斑为主要特征,严重影响患者的身心健康。白癜风的发病机制尚未阐明,主要与遗传学、氧化应激、自身免疫、炎症反应和神经化学递质等因素有关。近年来随着对白癜风发病机制的深入研究和流行病学数据的完善,有学者认为白癜风不仅仅是一种影响美观的皮肤病,还可能与机体代谢紊乱有关,白癜风常伴发代谢性疾病,如肥胖、血脂异常、糖耐量异常、糖尿病和高血压等。白癜风患者伴代谢性疾病限制了患者的治疗选择、增加药物相互作用风险,甚至增加病死率。目前对白癜风患者发生代谢性疾病的发病机制尚不清楚,本文就白癜风与代谢性疾病发病机制之间的联系进行综述,有助于临床的早期诊断并预防代谢性疾病的发生。Vitiligo is an acquired depigmentation skin disease characterized by depigmentation patches formed by the loss of epidermal melanocytes,which seriously affects the physical and mental health of patients.The pathogenesis of vitiligo has not yet been elucidated,mainly related to factors such as genetics,oxidative stress,autoimmunity,inflammatory response,and neurotransmitters.In recent years,with the in-depth study of the pathogenesis of vitiligo and the improvement of epidemiological data,some scholars believe that vitiligo is not only a skin disease that affects beauty,but also may be related to metabolic disorders.Vitiligo is often accompanied by metabolic diseases such as obesity,dyslipidemia,abnormal glucose tolerance,diabetes and hypertension.Vitiligo patients with metabolic diseases limit their treatment options,increase the risk of drug interactions,and even increase mortality.At present,the pathogenesis of metabolic diseases in vitiligo patients is not clear.This article reviews the relationship between vitiligo and metabolic diseases,which can help in early clinical diagnosis and prevent the occurrence of metabolic diseases.

关 键 词：白癜风 代谢性疾病 糖尿病 高脂血症 高血压 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]