补体C4d与IgA肾病研究进展  

Advances in complement C4d and IgA nephropathy

作　　者：傅嘉莹 田耘 李江徽 门妞妞 王睿琪 FU Jiaying;TIAN Yun;LI Jianghui;MEN Niuniu;WANG Ruiqi(The First Medicine College,Shaanri University of Chinese Medicine,Xianyang,Shaanri 712046,China;Department of Nephrology,Shaanri Hospital of Traditional Chinese Medicine,Xi'an,Shaanzi 710004,China)

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712046 [2]陕西省中医医院肾病科,陕西西安710004

出　　处：《中华实用诊断与治疗杂志》2025年第2期189-192,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金面上项目(81774123)。

摘　　要：IgA肾病是一种由半乳糖缺乏的IgA1和抗聚糖自身抗体形成引起的自身免疫性疾病。免疫复合物沉积激活补体凝集素途径,进一步导致局部炎性反应和肾小球损伤。补体C4d是补体C4的裂解产物,具有极高的稳定性,常作为补体系统经典及凝集素途径激活的下游标志物。补体C4d可反映IgA肾病补体活化强度,也可能参与IgA肾病的发生、发展,有望成为IgA肾病诊断、病情评估、疗效评价及预后预测的标志物。本文就补体C4d与IgA肾病的研究进展作一综述。IgA nephropathy is an autoimmune disease caused by the formation of galactose-deficient IgAl and antiglycan autoantibodies.Immune complex deposition activates the complement lectin pathway,which further leads to a localized inflammatory response and glomerular injury.Complement C4d is a cleavage product of complement C4,which is often used as a downstream marker of classical and lectin pathway activation in the complement system because of its extreme stability.It may reflect the intensity of complement activation in IgA nephropathy and may also be involved in the occurrence and development of IgA nephropathy.It is expected to be a marker for the diagnosis,disease evaluation,efficacy assessment and prognosis prediction of IgA nephropathy.This paper reviews the research progress of complement C4d and IgA nephropathy.

关 键 词：IGA肾病 补体系统 补体C4d 

分 类 号：R692.31[医药卫生—泌尿科学]