新癀片联合泛昔洛韦片治疗带状疱疹神经痛的临床效果  

Clinical efficacy of Xinhuang tablets combined with famciclovir tablets in the treatment of postherpetic neuralgia

作　　者：林开兴 林民毅 LIN Kaixing;LIN Minyi(Pain Department,the First Hospital of Putian City,Fujian Province,Putian 351100,China)

机构地区：[1]福建省莆田市第一医院疼痛科,351100

出　　处：《临床合理用药》2025年第9期40-43,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：莆田学院2023年科研项目(2023103)。

摘　　要：目的观察新癀片联合泛昔洛韦片治疗带状疱疹神经痛的临床效果。方法回顾性选取2021年1月—2023年10月莆田市第一医院疼痛科收治的带状疱疹神经痛患者118例,依据用药方法不同分为联合用药组和泛昔洛韦组,各59例。泛昔洛韦组采用泛昔洛韦片口服治疗1周,联合用药组在泛昔洛韦组基础上采用新癀片口服治疗3周。比较2组临床疗效,用药前后症状评分及相关量表评分[焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、现实疼痛强度(PPI)评分、视觉模拟评分法(VAS)评分、疼痛分级指数(PRI)评分、睡眠干扰评分量表(SIS)评分、匹兹堡睡眠质量指数(PSQI)评分、健康调查量表36(SF-36)评分]、血常规[白细胞计数(WBC)、淋巴细胞计数(LC)、C反应蛋白(CRP)],症状改善时间及不良反应。结果联合用药组总有效率为96.61%,高于泛昔洛韦组的76.27%(χ^(2)=10.412,P=0.001)。用药后,2组症状评分及SAS、SDS、PPI、VAS、PRI、SIS、PSQI评分低于用药前,SF-36评分高于用药前,且联合用药组降低/升高幅度大于泛昔洛韦组(P<0.01);2组WBC、LC及CRP水平低于用药前,且联合用药组低于泛昔洛韦组(P<0.01)。联合用药组疼痛缓解时间、止疱时间、结痂时间、止痛时间均短于泛昔洛韦组(P<0.01)。联合用药组不良反应总发生率为6.78%,低于泛昔洛韦组的20.34%(χ^(2)=4.627,P=0.031)。结论新癀片联合泛昔洛韦片治疗带状疱疹神经痛的临床疗效较好,可快速、有效改善临床症状,减轻疼痛程度,维持情绪稳定,提高睡眠质量及生活质量,且安全性较高。Objective To observe clinical efficacy of Xinhuang tablets combined with famciclovir tablets in the treatment of postherpetic neuralgia.Methods Retrospectively selected 118 patients with postherpetic neuralgia admitted to the pain department of the First Hospital of Putian City from January 2021 to October 2023,which were divided into famnciclovir group and the combined drug group based on the different methods of medication,with 59 cases each.Patients in famnciclovir group were treated with famciclovir tablets orally for 1 week,while patients in the combined drug group were treated with Xinhuang tablets orally for 3 weeks on the basis of famnciclovir group.Both groups continued to take drugs for 3 weeks.The clinical efficacy,symptom score and related scale scores(SAS score,SDS score,PPI score,VAS score,PRI score,SIS score,PSQI score,SF-36 score),blood routine(WBC,LC,CRP)before and after medication,symptom improvement time and adverse reactions were compared between the two groups.Results The total effective rate of the combined drug group was 96.61%,which was higher than that of famnciclovir group(76.27%)(χ^(2)=10.412,P=0.001).After medication,the scores of symptoms,SAS,SDS,PPI,VAS,PRI,SIS and PSQI in the two groups were lower than those before medication,and SF-36 score was higher than that before medication,and the combined drug group were lower/higher than those of famnciclovir group(P<0.01).WBC,LC and CRP level in the two groups were lower than before medication,and those in the combined drug group were lower than those of famnciclovir group(P<0.01).The pain relieving time,blister stopping time,scabbing time and analgesic time in the combined drug group were shorter than those of famnciclovir group(P<0.01).The total incidence of adverse reactions in the combined drug group was 6.78%,which was lower than that of famnciclovir group(20.34%)(χ^(2)=4.627,P=0.031).Conclusion Xinhuang tablets combined with famciclovir tablets have a good clinical effect in the treatment of postherpetic neuralgia,which can improve

关 键 词：带状疱疹神经痛 新癀片 泛昔洛韦片 疼痛程度 症状改善时间 不良反应 

分 类 号：R47[医药卫生—护理学]