多磺酸黏多糖乳膏治疗慢性湿疹对皮肤屏障功能的影响  

Effect of mucopolysaccharide polysulfate cream on skin barrier function in patients with chronic eczema

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作  者:张丹妮 廖玲 王志鹏 ZHANG Danni;LIAO Ling;WANG Zhipeng(Department of Dermatology,Shangrao People's Hospital,Shangrao,Jiangxi,334000,China;Department of General,Shangrao People's Hospital,Shangrao,Jiangxi,334000,China)

机构地区:[1]上饶市人民医院皮肤科,江西上饶334000 [2]上饶市人民医院全科,江西上饶334000

出  处:《当代医学》2024年第34期55-58,共4页Contemporary Medicine

摘  要:目的分析多磺酸黏多糖乳膏对慢性湿疹患者皮肤屏障功能的影响。方法选取2021年6月至2022年11月上饶市人民医院收治的80例慢性湿疹患者作为研究对象,按照随机数字表法分为对照组与实验组,每组40例。对照组使用曲安奈德益康唑乳膏治疗,实验组在对照组基础上使用多磺酸黏多糖乳膏治疗。比较两组症状积分、皮肤状态、不良反应发生情况、疾病复发情况及临床疗效。结果治疗后,两组皮肤颜色、皮肤硬度、病损厚度、瘙痒程度评分均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05)。实验组透明质酸酶合成增长率高于对照组,差异有统计学意义(P<0.05);治疗后,两组皮肤水份维持情况、皮肤油脂均高于治疗前,经皮水分散失(trans epidermal water loss,TEWL)均低于治疗前,且实验组皮肤水份维持情况、皮肤油脂均高于对照组,TEWL低于对照组,差异有统计学意义(P<0.05)。实验组疾病复发率为7.50%,低于对照组的25.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。治疗后,两组生理功能、日常活动、精神状态、学习与工作、社会交往评分均高于治疗前,且实验组高于对照组,差异有统计学意义(P<0.05)。实验组治疗总有效率为90.00%,高于对照组的72.50%,差异有统计学意义(P<0.05)。结论多磺酸黏多糖乳膏治疗慢性湿疹效果显著,有助于恢复患者皮肤屏障功能,降低临床体征评分及疾病复发率,具有较高的安全性。Objective To analyze the effect of mucopolysaccharide polysulfate cream on skin barrier function in patients with chronic eczema.Methods A total of 80 patients with chronic eczema who were admitted to Shangrao People's Hospital from June 2021 to November 2022 were selected as the research subjects,they were divided into the control group and the experimental group according to random number table,40 cases in each group.The control group was treated with triamcinolone acetonide and econazole nitrate cream,while the experimental group was treated with mucopolysaccharide polysulfate cream on the basis of the control group.Symptom scores,skin condition,occurrence of adverse reactions,recurrence and clinical efficacy were compared between the two groups.Results After treatment,the scores of skin color,skin hardness,lesion thickness and pruritus degree of the two groups were lower than those before treatment,and the experimental group was lower than the control group,and the differences were statistically significant(P<0.05).The growth rate of hyaluronidase synthesis in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the skin moisture maintenance and skin grease of the two groups were higher than those before treatment,and the trans epidermal water loss(TEWL)was lower than that before treatment,and the skin moisture maintenance and skin grease in the experimental group were higher than those in the control group,and the TEWL was lower than that in the control group,and the differences were statistically significant(P<0.05).The recurrence rate of disease in the experimental group was 7.50%,which was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.After treatment,the scores of physiological function,daily activities,mental state,learning and work,and social interaction of the two groups were

关 键 词:多磺酸黏多糖乳膏 慢性湿疹患者 皮肤屏障功能 临床体征评分 

分 类 号:R47[医药卫生—护理学]

 

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