Yolk-shelled silver nanowire@amorphous metal-organic framework for controlled drug delivery and light-promoting infected wound healing  

作　　者：Yueyan Yang Xu Sun Shengyan Wang Zhe Tang Siyuan Luo Jianjun Shi Xiaolu Zhuo Jinjin Zhu Han Zhang Xiangdong Kong 

机构地区：[1]Institute for Smart Biomedical Materials,School of Materials Science&Engineering,Zhejiang Sci-Tech University,Hangzhou 310000,PR China [2]Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,PR China [3]School of Science Engineering,The Chinese University of Hong Kong,Shenzhen,Guangdong 518172,PR China [4]Department of Orthopaedic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine&Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang,Hangzhou 310016,PR China

出　　处：《Regenerative Biomaterials》2025年第1期58-71,共14页再生生物材料(英文版)

基　　金：support from the Key Research and Development Program of Zhejiang Province[2021C01180];University Development Fund[UDF01002665,CUHK-Shenzhen];the Research Initiation Fund Project from Zhejiang Sci-Tech University[22212012-Y];Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ24F050005.

摘　　要：Bacteria-infected wounds healing has been greatly hindered by antibiotic resistance and persistent inflammation.It is crucial to develop multifunctional nanocomposites that possess effective antibacterial properties and can simultaneously accelerate the wound healing process to overcome the above challenges.Herein,we prepared a yolk–shell structured Ag nanowires(NWs)@amorphous hollow ZIF-67 by etching ZIF-67 onto the Ag NWs for infected wound healing for the first time.The etched hollow structure of amorphous ZIF-67 in the nanocomposite makes it a promising platform for loading healingpromoting drugs.We extensively studied the antibacterial and healing-promoting properties of the curcumin(CCM)-loaded nanocomposite(Ag NWs@C-HZ67).Ag NWs,being noble metal materials with plasmonic effects,can absorb a broad range of natural light and convert it to thermal energy.This photothermal conversion further improves the release of antibacterial components and wound healing drugs when exposed to light.During the healing process of an infected wound,Ag and Co ions were released from Ag NWs@C-HZ67 upon direct contact with the wound exudate and under the influence of light irradiation.Simultaneously,the loaded CCM leaked out to repair the infected wound.The minimum inhibitory concentrations of the Ag NWs@C-HZ67 groups against Escherichia coli and Staphylococcus aureus bacteria decreased to 3 and 3μg ml−1 when exposed to white light.Furthermore,an in vivo assessment of infected wound healing demonstrated that combining Ag NWs@C-HZ67 with light significantly accelerated the wound healing process,achieving 70%healing by the 6th day and almost complete healing by the 8th day.This advanced nanocomposite,consisting of components that possess antibacterial and growth-promoting properties,offers a safe,effective and clinically-translatable solution for accelerating the healing process of infected wounds.

关 键 词：plasmonic nanocomposites multifunctionality amorphous metal-organic framework controlled drug delivery infected wound healing 

分 类 号：TB3[一般工业技术—材料科学与工程]