MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing  

作　　者：Sheng Dai Lang Jiang Luying Liu Zhaogui Su Li Yao Ping Yang Nan Huang 

机构地区：[1]Institute of Biomedical Engineering,College of Medicine,Southwest Jiaotong University,Chengdu,Sichuan 610031,China [2]Key Laboratory of Advanced Technologies of Materials Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,Sichuan 610031,China [3]Air Force Medical Center,PLA,Beijing 100074,China [4]Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients and Controlled Release Preparations,College of Medicine and Nursing,Dezhou University,Dezhou 253023,China

出　　处：《Regenerative Biomaterials》2025年第1期156-169,共14页再生生物材料(英文版)

基　　金：supported by the National Natural Science Foundation of China(NSFC 32071320).

摘　　要：Poor wound healing in diabetics is primarily caused by persistently high levels of inflammation and recurrent bacterial infections.The catalytic therapy technique based on nanozyme medicine has emerged as a beacon of hope for patients with diabetic wounds.However,the use of a single-atom nanozyme may still have limitations,including nanozyme burst release,immunological clearance and insufficient antibacterial activity.To address the aforementioned problems,we provide a new nano-catalytic therapeutic agent for diabetic skin ulcers that incorporates a single-atom nanozyme with high antioxidant activity into a metal–organic framework(ZIF-Cu/C-dots).First,a Cu single-atom nanozyme supported by ultra-small carbon dots(Cu/C-dots)with high antioxidant activity was created.A nanozyme-integrated metal–organic framework was then created,utilizing Cu/C-dots as ligands and Zn2þas the core metal.Cu/C-dots have good oxidase-like activity,shielding the biological system from ROS damage and reducing the expression of TNF-αand IL-1β.Zn2þalso has good antibacterial activity(the antibacterial rate was more than 90%).This integrated technique prevents nanozyme aggregation,improves nanozyme biocompatibility,slows down the breakdown of ZIF and allows for the regulated release of Cu/C-dots and Zn2þas needed.Finally,in vivo studies have shown that ZIF-Cu/C-dots can effectively alleviate inflammation at the site of diabetic wounds,accelerate vascular regeneration,promote collagen deposition and enhance tissue remodeling,serving as a novel nano-catalytic platform for the treatment of wounds that are difficult to heal.

关 键 词：diabetic wounds single-atom nanozyme antioxidant activity antibacterial activity nano-catalytic platform 

分 类 号：O64[理学—物理化学]