白假丝酵母菌与阴道微生态的关系研究进展  

Research progress on relationship between Candida albicans and vaginal microecology

作　　者：谭灵俊 王彬 TAN Lingjun;WANG Bin(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Dali University,Dali 671000,China;不详)

机构地区：[1]大理大学第一附属医院妇产科,云南大理671000 [2]大理大学临床医学院,云南大理671000

出　　处：《山东医药》2025年第3期150-154,共5页Shandong Medical Journal

基　　金：云南省教育厅科学研究基金资助项目(2024Y910)。

摘　　要：阴道微生态是女性体内微生态系统的重要组成部分,主要由阴道解剖结构、微生物菌群、机体内分泌调节系统及阴道局部免疫系统构成,共同维持阴道微生态系统的动态平衡。阴道真菌菌群是定植于阴道内所有真菌种类所携带的遗传物质(包括基因组与特定基因)的集合体,其中最常见的条件致病菌为白假丝酵母菌,其生长通常受到其他微生物的影响和宿主免疫系统的抑制。在阴道内,就菌群数量而言,尽管真菌(以白假丝酵母菌为主)的数量远远不及细菌,但真菌在维护许多健康女性阴道生态系统的平衡中扮演着不可或缺的角色。白假丝酵母菌作为阴道菌群常见的定植真菌,其结构和数量的改变不仅可导致外阴阴道白假丝酵母菌病的发生,其本身与周围细菌菌群及宿主免疫系统之间的相互影响在阴道各类疾病的发生过程中也起到关键作用。Vaginal microecology is an important part of female microecosystem,which is mainly composed of vaginal anatomy,microflora,endocrine regulation system and vaginal local immune system,which jointly maintain the dynamic balance of vaginal microecosystem.Vaginal fungal flora is a collection of genetic material(including genomes and specific genes)carried by all fungal species colonized in the vagina,among which the most common opportunistic bacteria is Candida albicans,whose growth is usually affected by other microorganisms and suppressed by the host immune system.In terms of the number of bacteria in the vagina,although the number of fungi(dominated by Candida alba)is not as large as the number of bacteria,fungi play an integral role in maintaining the balance of the vaginal ecosystem in many healthy women.Candida albicans is a common colonizing bacterium of vaginal flora.The change of its structure and quantity can not only lead to the occurrence of vulvovaginal candida albicans disease,but also play a key role in the occurrence of various vaginal diseases through the interaction between Candida albicans itself,surrounding bacterial flora and host immune system.

关 键 词：白假丝酵母菌 外阴阴道白假丝酵母菌病 阴道微生态 白色念珠菌病 

分 类 号：R711.31[医药卫生—妇产科学]