血液灌流救治急性药物中毒患者采取综合干预措施的疗效研究  

Efficacy of Comprehensive Intervention Measures in the Treatment of Acute Drug Poisoning with Hemoperfusion

作　　者：张莉[1] 穆丽 ZHANG Li;MU Li(The First People's Hospital of Zunyi City,Zunyi 563000,China)

机构地区：[1]遵义市第一人民医院急诊科,贵州遵义563000

出　　处：《中华灾害救援医学》2025年第2期164-166,171,共4页Chinese Journal of Disaster Medicine

摘　　要：目的分析综合干预措施在急性药物中毒实施血液灌流治疗的患者中的临床疗效及价值。方法选择2020年5月至2024年5月遵义市第一人民医院救治的60例急性药物中毒患者为研究对象进行回顾性分析,根据干预方式的不同分为观察组(采取综合干预治疗)和对照组(常规干预治疗),每组30例。比较两组患者的临床症状缓解时间、救治结果、疾病严重程度及营养状况、不良反应发生情况。结果观察组患者清醒时间、意识恢复时间及住院时间均较对照组显著缩短(P<0.001)。观察组患者的生存率显著高于对照组患者,死亡率显著低于对照组,差异有统计学意义(P<0.05)。干预前,两组患者疾病严重程度APACHEII评分及营养状况PG-SGA评分无显著差异(P>0.05)。干预后,观察组患者的APACHEII评分及PG-SGA评分均显著低于对照组(P<0.001)。观察组患者的不良反应发生率显著低于对照组(P<0.05)。结论对于急性药物中毒实施血液灌流治疗的患者,综合干预措施可有效促进临床症状的恢复,降低患者死亡率,改善患者的疾病程度和营养状态,降低不良反应的发生风险。Objective To analyze the clinical efficacy and value of comprehensive intervention measures in patients undergoing blood purification treatment for acute drug poisoning.Methods A retrospective analysis was conducted on 60 patients with acute drug poisoning treated at Zunyi First People's Hospital from May 2020 to May 2024.Based on different intervention strategies,the patients were divided into an observation group(undergoing comprehensive intervention)and a control group(receiving conventional intervention),with 30 patients in each group.The clinical symptom relief time,treatment outcomes,disease severity,nutritional status,and incidence of adverse reactions were compared between the two groups.Results The time to wakefulness,time to regain consciousness,and length of hospital stay in the observation group were significantly shorter than those in the control group(P<0.001).The survival rate in the observation group was significantly higher,while the mortality rate was significantly lower compared to the control group,demonstrating statistical significance(P<0.05).Prior to intervention,there were no significant differences in disease severity(APACHE II score)and nutritional status(PGSGA score)between the two groups(P>0.05).Post-intervention,both the APACHE II score and PG-SGA score in the observation group were significantly lower than those in the control group(P<0.001).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion For patients undergoing blood purification treatment for acute drug poisoning,comprehensive intervention measures effectively promote the recovery of clinical symptoms,reduce mortality rates,improve disease severity and nutritional status,and decrease the risk of adverse reactions.

关 键 词：急性药物中毒 血液灌流 疗效 

分 类 号：R595.4[医药卫生—内科学]