有氧结合抗阻运动对卵巢癌患者干预效果的系统评价  

A systematic review of intervention effect on aerobic combined with resistance exercise in patients with ovarian cancer

作　　者：冯欣悦 张海月 梁冠冕[4] 徐毓露 李欢 楼妍[1] FENG Xinyue;ZHANG Haiyue;LIANG Guanmian;XU Yulu;LI Huan;LOU Yan(School of Nursing,Hangzhou Normal University,Hangzhou 311121,Zhejiang,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,Henan,China;The First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu,China;Department of Nursing,Zhejiang Cancer Hospital,Hangzhou 310022,Zhejiang,China)

机构地区：[1]杭州师范大学护理学院,浙江杭州311121 [2]郑州大学第一附属医院,河南郑州450003 [3]苏州大学附属第一医院,江苏苏州215006 [4]浙江省肿瘤医院护理部,浙江杭州310022

出　　处：《护士进修杂志》2025年第6期636-644,共9页Journal of Nurses Training

基　　金：国家自然科学基金项目(编号:71804039);浙江省自然科学基金探索公益项目(编号:LTCY23H160003)。

摘　　要：目的系统评价有氧结合抗阻运动在卵巢癌患者中的干预效果。方法计算机检索PubMed、Cochrane Library、Embase、Web of Science、知网、维普、万方、中国生物医学文献服务系统等数据库中有关有氧结合抗阻运动对卵巢癌患者干预效果的随机对照试验(randomized controlled trial,RCT)或类试验,检索时限从建库至2024年1月9日。由2名研究人员进行独立筛选、数据提取和质量评价,采用RevMan 5.4软件进行meta分析。结果共纳入6篇文献,包括3项RCT和3项类实验,共444例患者。meta分析结果显示,有氧结合抗阻运动能够缓解患者癌因性疲乏[SMD=-0.85,95%CI(-1.50,-0.20),P=0.01];改善患者的情绪功能[SMD=0.25,95%CI(0.03,0.47),Z=2.21,P=0.03]、身体功能[SMD=0.50,95%CI(0.28,0.73),Z=4.38,P<0.001]、社会功能[SMD=0.23,95%CI(0.00,0.45),Z=2.00,P=0.05];但肌肉力量证据不足,其他指标如健康相关生活质量、睡眠质量、最大摄氧量差异无统计学意义(P>0.05)。结论有氧结合抗阻运动能缓解卵巢癌患者的癌因性疲乏,改善其情绪功能、身体功能和社会功能,可为临床医护人员开展运动干预提供参考。Objective To systematically review the intervention effect of aerobic combined with resistance exercise intervention in patients with ovarian cancer.Methods The randomized controlled trials(RCT)or class experiment of aerobic combined with resistance exercise on interventions in ovarian cancer patients in the databases of PubMed,Cochrane Library,Embase,Web of Science,CNKI,VIP,WanFang,and SinoMed were searched by computer,with a search time frame from database creation to January 9,2024.Independent screening,quality evaluation,and data extraction were performed by 2 researchers,and meta-analysis was performed using RevMan 5.4 software.Results A total of 6 articles were included,including 3 randomised controlled trials,and 3 class trials with 444 patients.The results of meta-analysis showed that aerobic combined with resistance exercise alleviated cancer-caused fatigue in patients[SMD=-0.85,95%CI was(-1.50,-0.20),P=0.01],and improved emotional functioning[SMD=0.25,95%CI was(0.03,0.47),Z=2.21,P=0.03],physical functioning[SMD=0.50,95%CI was(0.28,0.73),Z=4.38,P<0.001],and social functioning[SMD=0.23,95%CI was(0.00,0.45),Z=2.00,P=0.05].However,there was insufficient evidence of muscular strength,and the differences of the other metrics of healthy related quality of life,sleep quality,and maximal oxygen uptake were not statistically significant(P>0.05).Conclusion Aerobic combined with resistance exercise can alleviate cancer-caused fatigue and improve emotional functioning,physical functioning,and social functioning in ovarian cancer patients,which can provide a reference for clinical healthcare professionals to carry out exercise intervention.

关 键 词：卵巢肿瘤 有氧运动 抗阻运动 系统评价 循证护理 

分 类 号：R47[医药卫生—护理学] R473.73[医药卫生—临床医学]