阿尔茨海默病患者腰椎骨密度与腹部脂肪含量的相关性研究  

Correlation between lumbar spine bone mineral density and abdominal adipose content in patients with Alzheimer′s disease

作　　者：胡月青 吕继辉[1] 杨燕英[2] 李文杰[1] 李沫[1] 贾东梅 张艳辉 HU Yueqing;LYU Jihui;YANG Yanying;LI Wenjie;LI Mo;JIA Dongmei;ZHANG Yanhui(Department of Cognitive Impairment,Beijing Geriatric Hospital,Beijing 100095,China;不详)

机构地区：[1]北京老年医院认知障碍科,北京100095 [2]北京老年医院放射科,北京100095 [3]北京老年医院骨科,北京100095

出　　处：《中国临床保健杂志》2025年第1期49-53,共5页Chinese Journal of Clinical Healthcare

基　　金：北京老年医院老年医学科研专项(2021-012);北京老年医院科研专项(2024-011)。

摘　　要：目的探讨阿尔茨海默病(AD)患者腰椎骨密度(BMD)与腹部脂肪含量的相关性。方法采用前瞻性对照研究,通过方便抽样,选取2021年12月至2023年12月到北京老年医院就诊62例AD患者作为病例组,并匹配同期就诊的62例认知正常老人为对照组。对受试者进行体重、身高、腰椎(L_(2~4))BMD、腹部总脂肪面积(TAA)、内脏脂肪面积(VAA)、皮下脂肪面积(SAA)的测量,并计算体重指数(BMI)和内壁比(V/S);比较2组间各指标的差异,并分析腰椎BMD与腹部脂肪含量之间的相关性。结果AD患者的体重、BMI、腰椎BMD(BMD_(L2)、BMD_(L3)、BMD_(L4)及平均BMD)以及SAA均显著低于对照组,差异有统计学意义(P<0.05);而VAA则显著高于对照组,差异有统计学意义(P<0.05)。在AD组中,BMD L2(r=0.26,P<0.05)、BMD_(L4)(r=0.29,P<0.05)及平均BMD与性别呈正相关(r=0.27,P<0.05),而BMD_(L4)下降与VAA的增加呈负相关(r=-0.26,P<0.05)。结论相较于认知正常的老人,AD患者的体重、BMI、腰椎BMD和皮下脂肪含量均呈现下降趋势,而内脏脂肪含量增加,且与BMD_(L4)的下降呈负相关。Objective To explore the correlation between lumbar bone mineral density(BMD)and abdominal adipose content in patients with Alzheimer′s disease(AD).Methods The study was a prospective control study.Through convenient sampling,62 AD patients who visited Beijing Geriatric Hospital from December 2021 to December 2023 were selected as the case group,and 62 cognitively normal elderly patients who visited during the same period were matched as the control group.The subjects were measured for weight,height,lumbar bone mineral density(L_(2-4)),total abdominal adipose area(TAA),visceral adipose area(VAA),subcutaneous adipose area(SAA),and body mass index(BMI)and visceral-to-subcutaneous(V/S)ratios were calculated.The differences of the indicators above were compared between the two groups and the correlation between BMD and abdominal adipose content was analyzed.Results The weight,BMI,lumbar bone density(BMD_(L2),BMD_(L3),BMD_(L4)and average BMD)and SAA of AD patients were significantly lower than those of the control group(P<0.05),while VAA was significantly higher than that of the control group(P<0.05).In the AD group,BMD_(L2)(r=0.26,P<0.05),BMD_(L4)(r=0.29,P<0.05),and average BMD were positively correlated with gender(r=0.27,P<0.05),whereas decreases in BMD_(L4)were significantly negatively correlated with increases in VAA(r=-0.26,P<0.05).Conclusions Compared to cognitively normal elderly,weight,BMI,lumbar BMD and SAA showed a decreasing trend in AD patients,while VAA is increased and negatively correlated with the decline in BMD_(L4).

关 键 词：阿尔茨海默病 骨密度 腹部脂肪面积 锥束计算机体层摄影术定量CT 老年人 

分 类 号：R58[医药卫生—内分泌]