中国社区老年人内在能力与三酰甘油葡萄糖乘积指数的关系  

Correlation between intrinsic capacity and triglyceride-glucose index in older adults from a Chinese community

作　　者：刘睿涵 刘昱彤 周翔 王小毛 张杰 田璠[3] 曹剑[1] Liu Ruihan;Liu Yutong;Zhou Xiang;Wang Xiaomao;Zhang Jie;Tian Fan;Cao Jian(Fourth Department of Healthcare,Second Medical Center.National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第二医学中心保健四科、国家老年疾病临床医学研究中心,北京100853 [2]解放军医学院 [3]解放军总医院第九医学中心特勤诊疗四科

出　　处：《中华老年心脑血管病杂志》2025年第4期445-449,共5页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：老年内在能力下降的评估与危险因素调查(21BJZ26)。

摘　　要：目的探讨三酰甘油葡萄糖乘积(triglyceride-glucose,TyG)指数与内在能力(intrinsic capacity,IC)的关系。方法采用横断面研究,选取2023年5~12月于万寿路社区进行问卷调查的老年人1000例,最终820例老年人纳入研究,根据TyG指数分为低TyG指数组(≤7.349)404例和高TyG指数组(>7.349)416例。倾向性评分匹配(propensity score matching,PSM)后共纳入患者522例,分为低TyG指数1组(≤7.349)261例和高TyG指数2组(>7.349)261例。采用单因素和多因素logistic回归分析IC与TyG指数作为连续变量和分类变量之间的关系;采用PSM分析来消除协变量的混杂效应,以发现不同分类中TyG指数与IC的关系。结果PSM前,低TyG指数组中性粒细胞、白细胞计数、同型半胱氨酸、空腹血糖、总胆固醇、三酰甘油、糖化血红蛋白显著低于高TyG指数组,淋巴细胞、单核细胞、天冬氨酸转氨酶显著高于高TyG指数组,差异有统计学意义(P<0.05,P<0.01)。PSM后,低TyG指数组空腹血糖、三酰甘油、糖化血红蛋白显著低于高TyG指数组(P<0.05,P<0.01)。TyG指数的ROC曲线分析显示,截断值为7.349。以7.349为截断值,即TyG指数作为分类变量,多因素logistic回归分析显示,TyG指数与IC相关[OR=3.921,95%CI:2.800~5.491,P=0.001(模型1);OR=2.744,95%CI:1.739~4.329,P=0.001(模型2);OR=2.744,95%CI:1.805~4.171,P=0.001(模型3);OR=2.722,95%CI:1.530~4.843,P=0.001(PSM后)],显示,TyG指数仍是IC的独立危险因素。结论IC与不基线资料的社区老年人在调整了相关实验室检查指标后仍相关。作为常规血液检查生成的指标,TyG指数在成本和时间方面具有优势。经过进一步验证,TyG指数可能为IC预测提供研究方向。Objective To investigate the relationship of TyG index and IC.Methods A cross-sectional study was conducted with 1000 older adults living in Wanshou Road Community from May to December 2023.Finally 820 participants were enrolled,and based on the TyG index,they were divided into lower TyG index group(≤7.349,404 cases)and higher TyG index group(>7.349,416 cases).After PSM,there were only 522 participants subjected,including 261 individuals in the lower TyG index group 1(≤7.349)and 416 ones in the higher TyG index group 2(>7.349).Univariate and multivariate logistic regression analyses were used to assess the correlation between IC and the TyG index as both continuous and categorical variables.PSM was employed to eliminate the confounding effects of covariates to identify the relationship between TyG index and IC in different categories.Results Before PSM,the neutrophil count,WBC count,and Hcy,FPG,TC,TG and HbA1c levels were significantly lower,and lymphocyte count,monocyte count,and AST level were obviously higher in the low TyG index group than the high TyG index group(P<0.05,P<0.01).After PSM,the low TyG index group still had notably lower FPG,TG and HbA1c than the high TyG index group(P<0.05,P<0.01).ROC curve analysis revealed that the cutoff value of TyG index was 7.349.Taking 7.349 as the cutoff value and TyG index as the categorical variable,multivariate logistic regression analysis displayed that TyG index was correlated with IC[OR=3.921,95%CI:2.800-5.491,P=0.001(Model 1);OR=2.744,95%CI:1.739-4.329,P=0.001(Model 2);OR=2.744,95%CI:1.805-4.171,P=0.001(Model 3);OR=2.722,95%CI:1.530-4.843,P=0.001(after PSM)],indicating that TyG index remains an independent risk factor for IC.Conclusion IC is still correlated with TyG index in community-dwelling elderly individuals under different baseline conditions after adjusting for relevant laboratory indicators.As an indicator generated from routine blood test,TyG index has advantages in terms of cost and time.With further validation,TyG may provide a direction for stud

关 键 词：老年人 横断面研究 数据相关性 LOGISTIC模型 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]